Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

814
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
814
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.4K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.4K
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

750
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
750
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

257
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
257
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

414
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
414
Guidelines for Nursing Documentation I01:30

Guidelines for Nursing Documentation I

1.7K
Quality documentation and reporting share essential characteristics that ensure they are practical and valuable resources for those who use them. These characteristics are:
Factual:  
The following points emphasize the significance of upholding accurate and unbiased documentation in healthcare.
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time to Reimplantation: Waiting Longer May Increase the Risk of Subsequent Failure.

The Journal of arthroplasty·2026
Same author

Deep Learning-Based Comparison of Knee Minimum Joint Space Width in Patients With Rheumatoid Arthritis and Osteoarthritis Before Total Knee Arthroplasty.

The Journal of rheumatology·2026
Same author

The Assessment of Coronal Plane Lower-Limb Alignment on Pre- and Postoperative Long-Leg Radiographs Using Deep Learning.

The Journal of arthroplasty·2026
Same author

Calming the Mind to Heal the Hip: Commentary on an article by Boyi Jiang, MD, et al.: "Significant Anxiolytic Effect and Enhanced Recovery Benefits of Perioperative Low-Dose Olanzapine in Patients with Anxiety Undergoing THA. A Randomized Controlled Trial".

The Journal of bone and joint surgery. American volume·2026
Same author

Minimum joint space width demonstrates higher inter-and intra-observer reliability than Kellgren-Lawrence grading in knee osteoarthritis.

Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA·2026
Same author

Comparison of Large Language Models with Rules-Based Natural Language Processing Algorithms for Extracting Data from Operative Notes.

The Journal of bone and joint surgery. American volume·2026

Related Experiment Video

Updated: Dec 23, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.8K

Implementation of Procedure-Specific Opioid Guidelines: A Readily Employable Strategy to Improve Consistency and

Cody C Wyles1, Mario Hevesi1, Daniel S Ubl1

  • 1Department of Orthopedic Surgery (C.C.W., M.H., R.T.T, N.S.T., M.W.P., and T.M.M.), Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Surgical Outcomes Program (D.S.U. and E.B.H.), and Division of Pain Medicine, Department of Anesthesiology and Perioperative Pain Medicine (H.M.G.), Mayo Clinic, Rochester, Minnesota.

JB & JS Open Access
|April 21, 2020
PubMed
Summary
This summary is machine-generated.

Procedure-specific opioid guidelines significantly reduced prescribing amounts by 38% without altering refill rates, indicating effective pain management and responsible opioid use in orthopaedic surgery.

More Related Videos

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
12:40

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia

Published on: September 28, 2022

2.0K
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.4K

Related Experiment Videos

Last Updated: Dec 23, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
14:56

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

21.8K
A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia
12:40

A Modified Murine Heterotopic Heart Transplant Protocol Matching Contemporary Standards of Aseptic Technique, Anesthesia, and Analgesia

Published on: September 28, 2022

2.0K
Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain
03:26

Author Spotlight: Advancements and Challenges in Surgical Treatments for Postamputation Pain

Published on: March 8, 2024

3.4K

Area of Science:

  • Orthopaedic Surgery
  • Pain Management
  • Pharmacology

Background:

  • Opioid prescribing guidelines are crucial for balancing pain relief and minimizing misuse.
  • Procedure-specific guidelines for orthopaedic surgery were developed to address prescribing variability.
  • This study evaluated the impact of these guidelines on opioid prescription quantities and refill rates.

Purpose of the Study:

  • To assess the effectiveness of procedure-specific opioid prescribing guidelines.
  • To evaluate changes in opioid prescription amounts and 30-day refill rates post-implementation.
  • To identify factors associated with exceeding guideline maximums.

Main Methods:

  • Retrospective cohort study (December 2016 - March 2018) at a single academic institution.
  • Compared 14 common orthopaedic procedures before (n=2,223) and after (n=2,300) guideline implementation (August 1, 2017).
  • Opioid quantities measured in oral morphine equivalents (OME); maximums ranged from 100-400 OME.

Main Results:

  • Median opioid prescriptions decreased by 38% (600 OME to 375 OME, p < 0.001).
  • 30-day refill rates remained unchanged (24% pre-guideline vs. 25% post-guideline, p = 0.43).
  • Guideline implementation strongly predicted exceeding maximums (OR=9.9); younger age and male sex also increased odds.

Conclusions:

  • Procedure-specific guidelines effectively reduce opioid prescription quantities and variability.
  • Pain management appears consistent with pre-guideline practices, as evidenced by stable refill rates.
  • These guidelines offer a practical solution for orthopaedic surgeons to improve responsible pain management.