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Related Concept Videos

Coagulation01:06

Coagulation

1.1K
Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
1.1K
Coagulation01:09

Coagulation

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The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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Evolution of viscoelastic coagulation testing.

Kenichi A Tanaka1, Reney A Henderson1, Erik R Strauss1

  • 1School of Medicine, University of Maryland , Baltimore, MD, USA.

Expert Review of Hematology
|April 21, 2020
PubMed
Summary
This summary is machine-generated.

Viscoelastic coagulation testing (VCT) devices guide bedside bleeding interventions. Performance varies by device, algorithms, and patients, necessitating tailored approaches for optimal use.

Keywords:
Bleedingcardiopulmonary bypasscoagulopathydirect oral anticoagulanthemodilutionsurgerytraumaviscoelastic coagulation testingwarfarin

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Area of Science:

  • Coagulation Science
  • Point-of-Care Testing
  • Hemostasis Management

Background:

  • Viscoelastic coagulation testing (VCT) methods have advanced significantly since thrombelastography's inception.
  • Modern VCT devices are utilized at the bedside to guide hemostatic interventions.
  • Clinical trials demonstrate VCT utility, but performance can differ across devices, algorithms, and patient groups.

Purpose of the Study:

  • To review working principles and current data on evolving VCTs for coagulation monitoring in acute care.
  • To synthesize evidence from PubMed regarding VCT performance and applications.

Main Methods:

  • Literature review of retrospective, prospective, and meta-analysis studies on VCTs.
  • Search of the PubMed database for relevant research.

Main Results:

  • Point-of-care VCTs offer insights into platelet count, fibrin polymerization, and procoagulant factors for acute bleeding (trauma, surgery) and antithrombotic therapy.
  • Fibrin-specific VCT channels highlight the importance of early fibrinogen correction and antifibrinolytic therapy.
  • Normal ranges and algorithms vary by device, requiring specific establishment for each indication.

Conclusions:

  • VCTs are valuable tools in acute care settings, providing critical hemostatic information.
  • Tailored diagnostic and treatment algorithms are essential for each VCT device and clinical indication.
  • Standardized protocols for complex conditions like hemophilia with inhibitors using VCTs are still under development.