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Targeting NAD-dependent dehydrogenases in drug discovery against infectious diseases and cancer

Davide M Ferraris1, Edoardo L M Gelardi1, Silvia Garavaglia1

  • 1Department of Pharmaceutical Sciences, University del Piemonte Orientale, Novara, Italy.

Biochemical Society Transactions
|April 21, 2020
PubMed

Insights

This review covers NAD-dependent dehydrogenases, crucial enzymes in diseases like cancer and infections. It highlights new drug development strategies targeting these enzymes for therapeutic applications.

Area of Science:

  • Biochemistry
  • Enzymology
  • Drug Discovery

Background:

  • Dehydrogenases are oxidoreductase enzymes vital for life.
  • NAD-dependent dehydrogenases are implicated in pathogen survival, infection, and cancer.
  • Targeting these enzymes offers therapeutic potential.

Purpose of the Study:

  • To review NAD-dependent dehydrogenases in human diseases.
  • To discuss advancements in targeting pathogen-associated NAD-dependent dehydrogenases.
  • To explore molecular inhibition strategies and novel compounds.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of enzyme structures and inhibition mechanisms.
  • Focus on compounds targeting dehydrogenases in cancer and infectious diseases.

Main Results:

  • Identification of key NAD-dependent dehydrogenases in disease pathogenesis.
  • Overview of current drug development efforts and inhibitory molecules.
  • Understanding of molecular interactions for targeted inhibition.

Conclusions:

  • NAD-dependent dehydrogenases are critical therapeutic targets.
  • Novel inhibitory compounds show promise for treating cancer and infections.
  • Further research into molecular inhibition can drive drug discovery.
Keywords:
NAD biologyNAD dehydrogenasescancerdrug discovery and designmalariatuberculosis

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