Related Experiment Video

Updated: Dec 23, 2025

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo
09:19

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

5.3K

Muscle stem cell aging: identifying ways to induce tissue rejuvenation

Pedro Sousa-Victor1, Joana Neves1, Pura Muñoz-Cánoves2

  • 1Instituto de Medicina Molecular (iMM), Faculdade de Medicina, Universidade de Lisboa, Lisbon, 1649-028, Portugal.

Mechanisms of Ageing and Development
|April 21, 2020
PubMed

Insights

Aging impairs tissue repair by reducing adult stem cell function. This study explores how skeletal muscle stem cells (satellite cells) decline with age and discusses new strategies to delay aging and enhance regeneration.

Area of Science:

  • Gerontology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Aging leads to a decline in tissue and organ function and regeneration.
  • Adult stem cells are crucial for tissue homeostasis and repair, but their function diminishes with age.
  • Skeletal muscle stem cells (satellite cells) are vital for muscle regeneration but fail in older individuals due to poorly understood reasons.

Purpose of the Study:

  • To review recent advances in understanding how satellite cells maintain function.
  • To explore how aging perturbs satellite cell integration of intrinsic and extrinsic factors, leading to regenerative failure.
  • To discuss potential therapeutic strategies for delaying satellite cell aging and improving regeneration.

Main Methods:

  • Review of current scientific literature on aging, stem cell biology, and skeletal muscle regeneration.
  • Analysis of intrinsic and extrinsic factors influencing satellite cell function.
  • Discussion of emerging anti-aging interventions.

Main Results:

  • Aging disrupts the integration of intrinsic and extrinsic processes governing satellite cell function.
  • This disruption results in the numerical and functional loss of satellite cells, impairing muscle regeneration.
  • Understanding these mechanisms opens avenues for therapeutic interventions.

Conclusions:

  • Satellite cell aging is a key factor in the regenerative decline observed in aging tissues.
  • Targeting satellite cell aging holds significant therapeutic potential for regenerative medicine.
  • Combining anti-aging strategies may offer novel approaches to enhance tissue repair in older individuals.
Keywords:
agingregenerationrejuvenationsarcopeniasatellite cellskeletal musclestem celltissue repair

More Related Videos

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans10:10

Preparation and Culture of Myogenic Precursor Cells/Primary Myoblasts from Skeletal Muscle of Adult and Aged Humans

Published on: February 16, 2017

22.5K
Author Spotlight: Investigating Cellular and Molecular Dynamics During Muscle Regeneration Using Cutting-Edge Single-Cell Technologies11:02

Author Spotlight: Investigating Cellular and Molecular Dynamics During Muscle Regeneration Using Cutting-Edge Single-Cell Technologies

Published on: December 1, 2023

1.4K

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.5K
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
2.0K
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.9K
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.2K
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
33.2K
Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
6.0K