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Updated: Dec 23, 2025
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
693
Chronic kidney disease in psoriasis: a cohort study
Andrea Conti1, Lisa Giovannini2, Victor Desmond Mandel1,3
1Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Summary
Psoriasis patients show increased risk for chronic kidney disease (CKD), particularly with longer disease duration and psoriatic arthritis. Microalbuminuria is linked to higher CKD risk stratification in these individuals.
Area of Science:
- Nephrology
- Dermatology
- Immunology
Background:
- Psoriasis is a chronic inflammatory disease with known comorbidities.
- Associations with cardiovascular and metabolic factors are established.
- Renal function impairment in psoriasis is under-researched.
Purpose of the Study:
- To investigate the association between psoriasis and chronic kidney disease (CKD).
- To evaluate CKD risk, eGFR, and albuminuria in psoriatic patients.
- To explore correlations with immunoglobulins and C3-C4 levels.
Main Methods:
- Cohort study of 219 psoriatic patients.
- Assessment of CKD and eGFR using KDIGO criteria.
- Measurement of urinary albumin-to-creatinine ratio and serum immunoglobulins.
Main Results:
- Moderate (17.35%), high (5.02%), and very high (3.66%) CKD risk identified.
- Risk prevalence for CKD was higher in patients without established risk factors compared to NHANES data.
- Psoriatic arthritis, longer psoriasis duration (≥21 years), and higher PASI scores correlated with albuminuria.
Conclusions:
- Microalbuminuria is associated with psoriasis duration and psoriatic arthritis.
- Patients with microalbuminuria had higher KDIGO CKD risk stratification.
- Psoriasis patients require monitoring for renal function impairment.
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