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MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

Carla Loreto1, Vera Filetti, Luis Eduardo Almeida

  • 1Department of Biomedical and Biotechnological Sciences, Section of Anatomy, University of Catania. carla.loreto@unict.it.

European Journal of Histochemistry : EJH
|April 22, 2020
PubMed

Insights

Matrix metalloproteinases (MMP-7 and MMP-9) are overexpressed in temporomandibular joint synovial tissue in patients with anterior disk displacement without reduction (ADDwoR). This indicates their role in severe temporomandibular joint dysfunction and joint disc remodeling.

Area of Science:

  • Biochemistry
  • Oral and Maxillofacial Surgery
  • Rheumatology

Background:

  • Matrix metalloproteinases (MMPs) are enzymes crucial for tissue remodeling, particularly in inflammatory conditions.
  • MMP-7 and MMP-9 are specifically involved in extracellular matrix balance and temporomandibular joint disc remodeling.

Purpose of the Study:

  • To investigate the association between MMP-7 and MMP-9 expression and severe temporomandibular joint dysfunction.
  • To specifically examine this relationship in cases of anterior disk displacement without reduction (ADDwoR).

Main Methods:

  • Immunohistochemical analysis was employed to assess MMP expression.
  • Human temporomandibular synovial tissues were collected from 20 patients with ADDwoR (test group) and 10 healthy controls.

Main Results:

  • A statistically significant difference (P<0.001) in morphometric and densitometric analysis was observed for both MMP-7 and MMP-9 between the control and test groups.
  • Both MMP-7 and MMP-9 showed overexpression in the synovial tissue of patients diagnosed with ADDwoR.

Conclusions:

  • MMP-7 and MMP-9 are significantly overexpressed in the synovial tissue of individuals suffering from ADDwoR.
  • These findings suggest a role for MMP-7 and MMP-9 in the pathophysiology of severe temporomandibular joint dysfunction, particularly ADDwoR.

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