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Viral infection related venous thromboembolism: potential mechanism and therapeutic targets

Yunan Yu1, Yuqin Shen1, Jie Li1

  • 1Department of Cardiology, Tongji Hospital of Tongji University, Shanghai 200065, China.

Annals of Palliative Medicine
|April 22, 2020
PubMed

With the development and improvement of new techniques in cell biology, molecular biology and biostatistics, increasing studies have been conducted to investigate the mechanism of venous thromboembolism (VTE). Some studies have found that the pathogenesis of VTE is largely related to the abnormality of the immune system as demonstrated by the thrombosis in mice infected with H1N1 influenza and the changes in the expression of genes related to immune system. According to the protein-protein interaction analysis of the differential expression of the immune system in VTE patients, the presence of venous thrombosis was related to the abnormal expression of molecules in JAK/STAT signaling pathway. We discussed the mechanism of VTE and provided two novel therapeutic targets for venous thrombosis: AKT1 and AOX1. Our review may be helpful for better understanding of the current research status of VTE, and provide evidence on the molecular mechanism of VTE.

Keywords:
JAK/STAT signaling pathwayVenous thromboembolism (VTE)viral infection

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