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Multicentric and diffuse recurrences of meningiomas
Francesco Maiuri1, Giuseppe Mariniello1, Carmela Peca1
1Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, Naples, Italy.
British Journal of Neurosurgery
|April 22, 2020
Summary
Flat-shaped meningiomas and those with high Ki67 Li scores (≥ 4%) are more prone to diffuse recurrence. Multiple surgeries can lead to long-term survival in selected patients with specific tumor characteristics.
Area of Science:
- Neurosurgery
- Oncology
- Pathology
Background:
- Meningiomas exhibit a significant recurrence rate, ranging from 10-32% within 10 years.
- Identifying factors predicting recurrence patterns is crucial for patient management.
Purpose of the Study:
- To distinguish pathological and surgical predictors of multicentric-diffuse versus local-peripheral meningioma recurrence.
- To analyze risk factors associated with different recurrence patterns.
Main Methods:
- Retrospective analysis of 33 patients with multicentric-diffuse meningioma recurrence compared to 50 with local-peripheral recurrence.
- Evaluation of factors including tumor shape, Ki67 proliferation index, WHO grade, and extent of resection.
Main Results:
- Flat-shaped meningiomas and those with Ki67 Li ≥ 4% were significantly associated with multicentric-diffuse recurrence.
- Other analyzed factors did not show significant differences between recurrence patterns.
Conclusions:
- Meningiomas with flat morphology and high Ki67 Li index (≥ 4%) indicate a higher risk for multicentric-diffuse recurrence.
- Selected patients with specific tumor types may achieve long-term survival through multiple reoperations.
