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[Hormonal regulation of anabolic processes and the rate of protein utilization in the early postnatal period]
L F Adigamov1, L I Smirnova, V D Nifontov
1Institut für Ernährung der Akademie, Medizinischen Wissenschaften der UdSSR, Moskau.
Insights
Thyroid and pituitary hormones, including thyroxine, triiodthyronine, and somatotropin, peak in 15-day-old rats. This hormone surge correlates with high protein utilization during early postnatal development.
Area of Science:
- Endocrinology
- Developmental Biology
- Animal Physiology
Context:
- Early postnatal development in rats is a critical period for growth and metabolic adaptation.
- Hormonal regulation plays a crucial role in orchestrating these developmental processes.
- Understanding the interplay between hormones and nutrient utilization is key to comprehending growth trajectories.
Purpose:
- To investigate the dynamic changes in key endocrine hormones and protein assimilation during the early postnatal period in rats.
- To determine the correlation between the production of anabolic hormones and protein utilization rates.
- To identify the specific developmental window characterized by peak hormone production and metabolic activity.
Summary:
- Thyroxine, triiodthyronine, and somatotropin levels were measured in rat serum and pituitary during early postnatal development.
- Peak endogenous production of these anabolic hormones was observed in 15-day-old infant rats.
- Protein assimilation was highest in 7-15-day-old rats, subsequently declining with the transition to definitive nutrition.
- A significant positive correlation was found between the production of thyroxine, triiodthyronine, somatotropin, and high protein utilization in early postnatal rats.
Impact:
- Provides insights into the hormonal control of growth and metabolism during a critical developmental phase.
- Highlights the importance of early nutrition and hormonal milieu for optimal development.
- Establishes a foundation for further research into endocrine-mediated growth disorders and nutritional interventions.
Abstract:
The levels of thyroid, pituitary and corticosteroid hormones--thyroxine, triiodthyronine, 11-oxicorticosteroids in blood serum, somatotropin in pituitary and processes of protein assimilation are studied in rats during early postnatal period. The highest endogen production of thyroxine, triiodthyronine and somatotropin is determined in 15 days old infant rats. The highest levels of protein utilization are determinated in 7-15 days old rats, then the process decreases with going over to definitive nutrition. Endogen production of anabolic hormones--thyroxine, triiodthyronine and somatotropin correlates to high levels of protein utilization in infant rats during the first days after birth.