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[Changes in serum human cartilage glycoprotein-39 and high-mobility group box 1 in preterm infants with
Yang Zhou1, Ling-Jian Meng, Jun Wang
1Department of Neonatology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221002, China. 664586331@qq.com.
Insights
Peripheral blood levels of human cartilage glycoprotein-39 (YKL-40) and high-mobility group box 1 (HMGB1) differ significantly in preterm infants with bronchopulmonary dysplasia (BPD). These findings suggest YKL-40 and HMGB1 may play a role in BPD development.
Area of Science:
- Neonatal Research
- Biomarker Discovery
- Pulmonology
Background:
- Bronchopulmonary dysplasia (BPD) is a common complication in preterm infants.
- Early identification of biomarkers for BPD is crucial for timely intervention.
Purpose of the Study:
- To investigate the dynamic changes in serum concentrations of human cartilage glycoprotein-39 (YKL-40) and high-mobility group box 1 (HMGB1).
- To determine the association of these biomarkers with the development of BPD in preterm infants.
Main Methods:
- Prospective study of preterm infants (gestational age 28-32 weeks, birth weight <1500g) from July 2017 to August 2019.
- Infants were divided into BPD (n=35) and non-BPD (n=51) groups.
- Serum YKL-40 and HMGB1 levels were measured using ELISA on days 3, 7, and 14 post-birth.
Main Results:
- Infants with BPD showed significantly lower YKL-40 and higher HMGB1 levels compared to the non-BPD group on days 3, 7, and 14 (P<0.001).
- Both YKL-40 and HMGB1 levels increased from day 3 to days 7 and 14 in both groups (P<0.017).
- Specific dynamic changes in YKL-40 and HMGB1 were observed between day 7 and day 14, differing between BPD and non-BPD groups.
Conclusions:
- Significant differences in YKL-40 and HMGB1 levels exist between preterm infants with and without BPD.
- These biomarkers show potential as indicators for BPD development.
- Further research is warranted to elucidate the precise role of YKL-40 and HMGB1 in BPD pathogenesis.
Objective:
To study the association of the dynamic changes of peripheral blood human cartilage glycoprotein-39 (YKL-40) and high-mobility group box 1 (HMGB1) with bronchopulmonary dysplasia (BPD) in preterm infants.
Methods:
Preterm infants, with a gestational age of 28-32 weeks and a birth weight of <1 500 g, who were admitted to the neonatal intensive care unit from July 2017 to August 2019 were prospectively selected and divided into a BPD group with 35 infants and a non-BPD group with 51 infants. ELISA was used to measure the serum concentrations of YKL-40 and HMGB1 in preterm infants on days 3, 7, and 14 after birth.
Results:
The BPD group had a significantly lower serum YKL-40 concentration and a significantly higher serum HMGB1 concentration than the non-BPD group on days 3, 7, and 14 (P<0.001). The serum concentrations of YKL-40 and HMGB1 on days 7 and 14 were significantly higher than those on day 3 in both groups (P<0.017). In the BPD group, HMGB1 concentration on day 14 was significantly higher than that on day 7 (P<0.017), while there was no significant change in YKL-40 concentration from day 7 to day 14 (P>0.017). In the non-BPD group, YKL-40 concentration on day 14 was significantly higher than that on day 7 (P<0.017), while there was no significant change in HMGB1 concentration from day 7 to day 14 (P>0.017).
Conclusions:
There are significant differences in the levels of YKL-40 and HMGB1 in peripheral blood between the preterm infants with BPD and those without BPD on days 3, 7, and 14 after birth, suggesting that YKL-40 and HMGB1 might be associated with the development of BPD.
