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Targeting FOXP3 complex ensemble in drug discovery.

Jingyao Huang¹, Shuoyang Wang¹, Yuxin Jia¹

¹Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Advances in Protein Chemistry and Structural Biology

|April 22, 2020

Summary

Forkhead Box P3 (FOXP3) regulates regulatory T cells (Tregs) crucial for immune homeostasis. Targeting FOXP3 offers potential for cancer and autoimmune disease immunotherapy by modulating Treg function.

Keywords:

Drug discovery FOXP3 Immune therapy Post-translational modification Treg

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Area of Science:

Immunology
Molecular Biology
Cell Biology

Background:

Forkhead Box P3 (FOXP3) is a master transcriptional regulator essential for regulatory T cell (Treg) development and function.
Tregs play a critical role in maintaining immune homeostasis and preventing autoimmunity.
Dysregulation of Treg function is implicated in various diseases, including cancer and autoimmune disorders.

Purpose of the Study:

To review the role of the transcription factor FOXP3 in regulatory T cells (Tregs).
To discuss the involvement of Treg functions in disease pathogenesis.
To explore FOXP3 targets and their potential as therapeutic strategies in immunotherapy.

Main Methods:

Literature review focusing on FOXP3, Treg biology, and disease associations.
Analysis of post-translational modifications affecting FOXP3 stability and function.
Examination of FOXP3's role within transcriptional complexes.

Main Results:

FOXP3 is central to Treg-mediated immune suppression, vital for immune balance.
FOXP3 activity is modulated by post-translational modifications influencing its function.
FOXP3 and its interacting partners represent promising targets for immunotherapeutic interventions.

Conclusions:

FOXP3 is a critical regulator of Treg-mediated immune suppression.
Understanding FOXP3's role in disease offers therapeutic opportunities.
Targeting FOXP3 pathways holds potential for novel immunotherapies in cancer and autoimmune diseases.