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Related Experiment Video

Updated: Dec 23, 2025

Sleeve Gastrectomy in Mice using Surgical Clips
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Altered systematic glucose utilization after gastrectomy: correlation with weight loss.

Arthur Cho1, In Gyu Kwon2, Soyoung Kim1

  • 1Department of Nuclear Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
|April 22, 2020
PubMed
Summary

Gastric cancer surgery significantly reduces weight and improves metabolism by altering glucose distribution. Increased small bowel and white adipose tissue (WAT) uptake after gastrectomy correlates with substantial weight loss.

Keywords:
(18) F-fluorodeoxyglucoseGastrectomyObesitySmall bowel

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Area of Science:

  • Metabolic Surgery
  • Oncology
  • Radiology

Background:

  • Gastrectomy for gastric cancer leads to weight loss and improved glucose homeostasis, but the underlying mechanisms remain unclear.
  • Post-gastrectomy weight loss may involve altered nutrient absorption and systemic endocrine changes, similar to bariatric surgery.
  • No prior studies have investigated altered glucose metabolism in relation to postoperative weight loss in gastric cancer patients.

Purpose of the Study:

  • To evaluate changes in glucose metabolism and weight following gastrectomy in gastric cancer patients.
  • To determine if increased glucose uptake in specific tissues correlates with weight loss after surgery.
  • To explore potential bariatric surgery-like endocrinologic changes post-gastrectomy.

Main Methods:

  • Retrospective analysis of 149 overweight gastric cancer patients who underwent gastrectomy.
  • Utilized 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) 6-12 months post-surgery.
  • Quantified glycolysis in the small bowel, subcutaneous white adipose tissue (WAT), and skeletal muscle, correlating uptake with ≥5% weight loss.

Main Results:

  • Significant reductions in weight (-3.3 kg), cholesterol (-15 mg/dL), and body fat (-26.1%) were observed post-surgery.
  • Increased 18F-fluorodeoxyglucose uptake in the small bowel was significantly correlated with substantial weight loss (≥5%).
  • Higher small bowel uptake was associated with increased WAT uptake (P = .01), and both were strongly linked to weight loss (OR: 9.67).

Conclusions:

  • Increased small bowel glycolysis and WAT uptake following gastrectomy predict significant weight loss.
  • Altered glucose distribution plays a key role in the metabolic improvements observed after gastrectomy.
  • Gastric cancer patients undergoing gastrectomy exhibit endocrinologic changes comparable to those seen after bariatric surgery.