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Suicidal Risks in 12 DSM-5 Psychiatric Disorders.

R J Baldessarini1, L Tondo2

  • 1International Consortium for Research on Mood & Psychotic Disorders, McLean Hospital, Belmont, Massachusetts, USA; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.

Journal of Affective Disorders
|April 22, 2020
PubMed
Summary

Suicidal risks, including ideation and attempts, are elevated across major psychiatric disorders. Bipolar disorder with psychotic or mixed features, substance abuse, and severe major depressive disorder pose the highest risks.

Keywords:
AttemptIdeationLethalityPsychiatric diagnosisRisk ratesSuicide

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Area of Science:

  • Psychiatry
  • Mental Health Research
  • Epidemiology

Background:

  • Large-scale studies on suicidal behaviors in psychiatric patients are infrequent.
  • Understanding comparative suicidal risks across diverse psychiatric diagnoses is crucial.

Purpose of the Study:

  • To compare suicidal ideation, attempts, and suicide rates across 12 prevalent DSM-5 psychiatric disorders.
  • To identify specific diagnoses with particularly high suicidal risks.

Main Methods:

  • Quantified suicidal ideation, lifetime suicide attempts, and violent acts in 6050 adult psychiatric patients.
  • Analyzed data from a European psychiatric center using DSM-5 diagnoses.

Main Results:

  • Suicidal ideation varied significantly, from 53.9% in bipolar disorder (BD) with mixed features to 8.70% in anxiety disorders.
  • Suicide rates were highest in substance abuse, BD with psychotic features, psychotic disorders, BD-I, and major depressive disorder (MDD).
  • BD with psychotic or mixed features, substance abuse, and severe MDD with hospitalization showed particularly high suicidal risks.

Conclusions:

  • Suicidal risks are notably elevated in specific psychiatric conditions, especially BD with psychotic/mixed features, substance abuse, and severe MDD.
  • Gender differences exist in suicidal behaviors, with women having higher ideation/attempts but men more violent acts/suicides.
  • Hospitalization status significantly impacts suicidal act rates in BD and MDD.