Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K
RNA-seq03:21

RNA-seq

11.6K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Normoalbuminaemia is associated with IgA nephropathy in primary glomerulopathy with nephrotic-range proteinuria in Chinese patients.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2010
Same author

[Effect of Shenqi compound on PTEN/PI3K signal transduction in GK rats with diabetes mellitus macroangiopathy].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2010
Same author

Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.

International journal of oncology·2010
Same author

Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant.

Vaccine·2010
Same author

A red-shifted chlorophyll.

Science (New York, N.Y.)·2010
Same author

Effect of the artificial somato-autonomic neuroanastomosis on defecation after spinal cord injury and its underlying mechanisms.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban·2010

Related Experiment Video

Updated: Dec 23, 2025

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq
09:08

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

Published on: November 13, 2017

18.4K

[ATAC-seq and its applications in complex disease].

Min Chen1, Zheng Zhang2, Zi Yuan Meng1

  • 1Department of Dermatology and Venerology, the First Affiliated Hospital of Anhui Medical University, Heifei 230022, China.

Yi Chuan = Hereditas
|April 22, 2020
PubMed
Summary
This summary is machine-generated.

Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) maps genome-wide chromatin accessibility. This technology aids in understanding disease pathogenesis, drug pharmacology, and biomarker development for complex diseases.

Keywords:
ATAC-seqTn5 transposasechromatin accessibilitytranscriptional level

More Related Videos

ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.1K
Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

4.0K

Related Experiment Videos

Last Updated: Dec 23, 2025

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq
09:08

Mapping Genome-wide Accessible Chromatin in Primary Human T Lymphocytes by ATAC-Seq

Published on: November 13, 2017

18.4K
ATAC-Seq Optimization for Cancer Epigenetics Research
07:13

ATAC-Seq Optimization for Cancer Epigenetics Research

Published on: June 30, 2022

5.1K
Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq
06:24

Multiplexed Analysis of Retinal Gene Expression and Chromatin Accessibility Using scRNA-Seq and scATAC-Seq

Published on: March 12, 2021

4.0K

Area of Science:

  • Genomics and Molecular Biology
  • Epigenetics and Gene Regulation

Background:

  • Chromatin accessibility is crucial for gene regulation and cellular function.
  • Understanding epigenetic modifications is key to deciphering complex diseases.

Purpose of the Study:

  • To review the applications and advantages of ATAC-seq.
  • To highlight ATAC-seq's role in understanding gene expression and disease.
  • To define prospective contributions of ATAC-seq to future research strategies.

Main Methods:

  • ATAC-seq utilizes Tn5 transposase enzymes to identify open chromatin regions.
  • Genome-wide mapping of chromatin accessibility.
  • Analysis of transcription-factor binding sites and nucleosome positioning.

Main Results:

  • ATAC-seq provides high-throughput quantification of chromatin accessibility.
  • Identifies regulatory elements involved in gene expression.
  • Enables genome-wide insights into epigenetic landscapes.

Conclusions:

  • ATAC-seq is a powerful tool for biomedical research and disease mechanism studies.
  • It facilitates drug development, biomarker discovery, and understanding gene regulation.
  • ATAC-seq offers significant potential for future research in complex diseases.