Related Experiment Video

Updated: Dec 23, 2025

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
09:15

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

3.8K

The p53 Saga: Early Steps in the Development of Tumor Immunotherapy

Albert B DeLeo1, Ettore Appella2

  • 1University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232; and.

Journal of Immunology (Baltimore, Md. : 1950)
|April 22, 2020
PubMed

Insights

The p53 tumor suppressor, initially identified 40 years ago, is crucial for cell cycle regulation and oncogenesis. Recent advances highlight its vital role in cancer immunotherapy and the tumor microenvironment.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • The protein p53 was first identified 40 years ago as a transformation-related antigen.
  • Initially pursued as a cancer vaccine candidate, p53's role has evolved significantly.
  • Advances in molecular oncology and immunology have reshaped our understanding of p53.

Purpose of the Study:

  • To review the evolving understanding of p53's function in cancer research.
  • To highlight p53's critical role in cell cycle regulation, oncogenesis, and immune responses.
  • To underscore the significance of p53 in basic and translational cancer research, including immunotherapy.

Main Methods:

  • Literature review and synthesis of key findings in p53 research.
  • Analysis of p53's function in normal tissues and the tumor microenvironment.
  • Examination of clinical advancements in p53-based cancer immunotherapy.

Main Results:

  • p53 is recognized as a key regulator of cell cycle control and oncogenesis.
  • p53 plays a critical role in immune recognition and responses within the tumor microenvironment.
  • p53-based cancer immunotherapy shows promising clinical implementation.

Conclusions:

  • The 40-year journey of p53 research has transformed it from a vaccine target to a central player in cancer biology.
  • p53's multifaceted roles in cell cycle, oncogenesis, and immunity are critical for cancer research and treatment.
  • Continued investigation into p53 is essential for advancing cancer immunotherapy and translational oncology.

More Related Videos

Yeast As a Chassis for Developing Functional Assays to Study Human P5314:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.9K
Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity06:16

Generation of Orthotopic Pancreatic Tumors and Ex vivo Characterization of Tumor-Infiltrating T Cell Cytotoxicity

Published on: December 7, 2019

13.3K

Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.5K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
871