Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Self-administered acupressure training for depression in community-dwelling individuals: a randomized controlled trial and cost-effectiveness analysis.

EClinicalMedicine·2026
Same author

Aligning Chemical Kinetics with Crystallization Enables Millimeter-Scale Single Crystals of Conductive MOFs.

Journal of the American Chemical Society·2026
Same author

Interlayer Electronic Decoupling Unlocks Giant Birefringence in π-Conjugated Metal-Organic Frameworks.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

A disulfide-Fe<sup>3+</sup> crosslinking strategy for tough hydrogel networks with complete photo- and biochemical degradability.

Materials horizons·2026
Same author

A β-1,3-glucanase antagonizes a phase-separating WRKY repressor to confer saline-alkaline tolerance in rice.

The New phytologist·2026
Same author

Mycoelectronics: Bioprinted living fungal bioelectronics for artificial sensation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells.

Nature biotechnology·2026
Same journal

A retargeted recombinase for precise insertion of large DNA.

Nature biotechnology·2026
Same journal

Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles.

Nature biotechnology·2026
Same journal

Spatially resolved profiling of extracellular vesicles in tissues with Spatial-EV-seq.

Nature biotechnology·2026
Same journal

Mapping the spatial landscape of extracellular vesicles in tissues with Spatial-EV-seq.

Nature biotechnology·2026
Same journal

Author Correction: Generation of modified cows and sheep from spermatid-like haploid embryonic stem cells.

Nature biotechnology·2026
See all related articles

Related Experiment Video

Updated: Dec 23, 2025

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
09:58

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

23.8K

Morphing electronics enable neuromodulation in growing tissue.

Yuxin Liu1, Jinxing Li2, Shang Song3

  • 1Department of Bioengineering, Stanford University, Stanford, CA, USA.

Nature Biotechnology
|April 22, 2020
PubMed
Summary
This summary is machine-generated.

Morphing electronics adapt to nerve growth, reducing the need for replacement surgeries in pediatric patients. This innovative bioelectronic approach minimizes tissue damage and supports long-term neural interfacing.

More Related Videos

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices
07:15

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

4.1K
Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

9.1K

Related Experiment Videos

Last Updated: Dec 23, 2025

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology
09:58

Syringe-injectable Mesh Electronics for Stable Chronic Rodent Electrophysiology

Published on: July 21, 2018

23.8K
Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices
07:15

Electric-Field-Induced Neural Precursor Cell Differentiation in Microfluidic Devices

Published on: April 14, 2021

4.1K
Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

9.1K

Area of Science:

  • Bioelectronic medicine
  • Biocompatible materials
  • Pediatric medical devices

Background:

  • Implanted bioelectronics for nervous system modulation show therapeutic potential for neurological disorders.
  • Current devices have fixed dimensions, leading to complications and repeated surgeries as pediatric patients grow.
  • Tissue growth can cause mechanical stress, impairing device function and patient development.

Purpose of the Study:

  • To develop novel morphing electronics that adapt to in vivo nerve tissue growth.
  • To overcome the limitations of fixed-dimension implants in pediatric and adolescent patients.
  • To create a seamless and reconfigurable neural interface that accommodates biological changes.

Main Methods:

  • Fabrication of multilayered morphing electronics with viscoplastic electrodes and a strain sensor.
  • Design to minimize mechanical constraint and stress at the tissue-electronics interface.
  • In vivo testing in rats during their fastest growth period to assess adaptability and biocompatibility.

Main Results:

  • Morphing electronics demonstrated self-healing capabilities during implantation.
  • The devices adapted to a 2.4-fold increase in nerve diameter in growing rats with minimal nerve damage.
  • Chronic electrical stimulation and monitoring were maintained for 2 months without functional behavioral disruption.

Conclusions:

  • Morphing electronics offer a growth-adaptive solution for pediatric electronic medicine.
  • This technology can reduce the need for revision surgeries in children and adolescents.
  • Enables long-term, stable neural interfacing in dynamic biological environments.