Related Experiment Video

Updated: Dec 23, 2025

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

21.7K

[Mesoamerican nephropathy - a new challenge for occupational physicians]

Katarzyna Kanclerz1, Wojciech Wołyniec1, Przemysław Rutkowski2

  • 1Gdański Uniwersytet Medyczny / Medical University of Gdańsk, Gdańsk, Poland (Klinika Chorób Zawodowych, Metabolicznych i Wewnętrznych / Department of Occupational, Metabolic and Internal Diseases).

Medycyna Pracy
|April 22, 2020
PubMed

Insights

Mesoamerican nephropathy (MeN) is a chronic kidney disease affecting agricultural workers in hot climates. Its exact cause is unknown, but occupational heat stress and dehydration are suspected contributors.

Area of Science:

  • Nephrology
  • Occupational Medicine
  • Environmental Health

Background:

  • Mesoamerican nephropathy (MeN) is an endemic chronic kidney disease (CKD) distinct from diabetes- or hypertension-related CKD.
  • Prevalence has significantly increased since the late 1990s, particularly in Central America and Southern Mexico.
  • High CKD mortality rates are reported in El Salvador, with a tenfold increase observed between 1984-2005.

Purpose of the Study:

  • To review the current understanding of Mesoamerican nephropathy (MeN).
  • To highlight the epidemiological and clinical characteristics of MeN.
  • To discuss the potential impact of occupational heat stress on MeN development.

Main Methods:

  • Literature review of endemic CKD in Mesoamerica.
  • Analysis of epidemiological data on CKD prevalence and mortality.
  • Histopathological findings in MeN patients.

Main Results:

  • MeN primarily affects male agricultural laborers in hot, dry environments.
  • Histological examination reveals tubulointerstitial lesions, sometimes with glomerular involvement.
  • Occupational heat stress and dehydration are implicated in disease development.

Conclusions:

  • The etiology of MeN remains unclear, necessitating further research.
  • MeN poses a significant socio-economic burden and diagnostic/therapeutic challenge.
  • Occupational health strategies are crucial for MeN prevention and management.
Keywords:
albuminuriachronic kidney diseaseendemic nephropathyevaluation of fitness for workmesoamerican nephropathypreventive care over employees

More Related Videos

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.4K
5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat08:50

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

24.2K

Related Concept Videos

Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
221
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
147
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
465
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
269
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
404
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
236