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[Mesoamerican nephropathy - a new challenge for occupational physicians]
Katarzyna Kanclerz1, Wojciech Wołyniec1, Przemysław Rutkowski2
1Gdański Uniwersytet Medyczny / Medical University of Gdańsk, Gdańsk, Poland (Klinika Chorób Zawodowych, Metabolicznych i Wewnętrznych / Department of Occupational, Metabolic and Internal Diseases).
Medycyna Pracy
|April 22, 2020
Summary
Mesoamerican nephropathy (MeN) is a chronic kidney disease affecting agricultural workers in hot climates. Its exact cause is unknown, but occupational heat stress and dehydration are suspected contributors.
Area of Science:
- Nephrology
- Occupational Medicine
- Environmental Health
Background:
- Mesoamerican nephropathy (MeN) is an endemic chronic kidney disease (CKD) distinct from diabetes- or hypertension-related CKD.
- Prevalence has significantly increased since the late 1990s, particularly in Central America and Southern Mexico.
- High CKD mortality rates are reported in El Salvador, with a tenfold increase observed between 1984-2005.
Purpose of the Study:
- To review the current understanding of Mesoamerican nephropathy (MeN).
- To highlight the epidemiological and clinical characteristics of MeN.
- To discuss the potential impact of occupational heat stress on MeN development.
Main Methods:
- Literature review of endemic CKD in Mesoamerica.
- Analysis of epidemiological data on CKD prevalence and mortality.
- Histopathological findings in MeN patients.
Main Results:
- MeN primarily affects male agricultural laborers in hot, dry environments.
- Histological examination reveals tubulointerstitial lesions, sometimes with glomerular involvement.
- Occupational heat stress and dehydration are implicated in disease development.
Conclusions:
- The etiology of MeN remains unclear, necessitating further research.
- MeN poses a significant socio-economic burden and diagnostic/therapeutic challenge.
- Occupational health strategies are crucial for MeN prevention and management.
Keywords:
albuminuriachronic kidney diseaseendemic nephropathyevaluation of fitness for workmesoamerican nephropathypreventive care over employeesMore Related Videos
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