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Isolated adrenocorticotrophic hormone deficiency in a patient treated with checkpoint inhibitor therapy

Azaan Ramani1, Taylor Maloney1, Brooke Mills1

  • 1Department of Internal Medicine, Baylor University Medical CenterDallasTexas.

Proceedings (Baylor University. Medical Center)
|April 22, 2020
PubMed

Treatment of advanced melanoma has significantly improved with the advent of checkpoint inhibitor therapy. With the widespread use of these agents, side effects are being increasingly recognized, including immune-related adverse events. We report the onset of adrenal insufficiency in a patient with advanced melanoma who was exposed to two checkpoint inhibitors: ipilimumab and nivolumab. His symptoms initially resolved with steroid replacement but he was unable to be weaned off hormone replacement and required long-term oral hydrocortisone treatment.

Keywords:
Adrenal insufficiencycheckpoint inhibitorcytotoxic T-lymphocyte antigen–4hypophysitisimmune-related adverse eventsipilimumabnivolumabprogrammed death–1

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