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Updated: Dec 23, 2025

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Multiple myeloma presenting as plasmacytoma causing obstructive jaundice.

Ted George Achufusi1, Anuj Sharma1, Bishnu Sapkota2

  • 1Department of Internal Medicine, SUNY Upstate Medical UniversitySyracuseNew York.

Proceedings (Baylor University. Medical Center)
|April 22, 2020
PubMed
Summary

Pancreatic plasmacytomas, rare plasma cell tumors, can mimic pancreatic cancer symptoms like jaundice and weight loss. This case highlights their diagnosis via endoscopic ultrasound-guided fine-needle aspiration, especially with multiple myeloma.

Keywords:
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Area of Science:

  • Oncology
  • Hematology

Background:

  • Pancreatic malignancies often present with jaundice, weight loss, and anorexia, commonly associated with pancreatic adenocarcinoma.
  • However, not all pancreatic malignancies originate from the exocrine pancreas; plasma cell tumors, or plasmacytomas, can also occur.
  • Plasmacytomas are classified as intramedullary (inside bone marrow) or extramedullary (outside bone marrow), with intramedullary types being more frequent.

Observation:

  • This report details a rare case of pancreatic plasmacytoma.
  • The patient presented with symptoms suggestive of pancreatic malignancy.
  • The diagnosis was established in the context of advanced multiple myeloma.

Findings:

  • Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) was instrumental in diagnosing the pancreatic plasmacytoma.
  • This diagnostic approach allowed for tissue acquisition and definitive characterization of the tumor.
  • The case underscores the importance of considering non-adenocarcinoma etiologies in pancreatic masses.

Implications:

  • Accurate diagnosis of pancreatic plasmacytoma is crucial for appropriate treatment and patient management.
  • EUS-FNA is a valuable tool for diagnosing rare pancreatic tumors.
  • This case expands the understanding of plasma cell neoplasm manifestations and diagnostic strategies.