Related Experiment Video
Updated: Dec 23, 2025

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Abdominal Malignancy with Skin Manifestation and Thromboembolic Disease: An Unusual Presentation
Raguraj Chandradevan1, Jennifer Espinal1, Marika Shahid1
1Internal Medicine, Coliseum Medical Centers, Macon, USA.
Abstract:
A 55-year-old male presented to our hospital with shortness of breath and leg swelling. Imaging studies revealed deep vein thrombosis and bilateral pulmonary embolism. The patient was placed on anticoagulation. A palpable umbilical nodule consistent with the appearance of Sister Mary Joseph's nodule (SMJN) raised the possibility of an underlying gastrointestinal malignancy. The patient also had significant ascites and underwent paracentesis with cytology, upper gastrointestinal and lower gastrointestinal endoscopy with the biopsy. Gastric lesion histology revealed gastric adenocarcinoma with peritoneal and colonic metastases. The patient was started on chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin (FOLFOX) for disseminated gastric malignancy. SMJN is a rare cutaneous metastatic manifestation which needs to be considered as a differential diagnosis of an umbilical tumor for prompt diagnosis and initiation of treatment.
Related Concept Videos
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Esophageal Varices-II: Clinical Features and Management
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Aneurysm II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis I: Introduction
