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Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
Published on: February 13, 2021
Heart Failure with Preserved Ejection Fraction: Can Device Therapy Be Our Option?
1Internal Medicine, University of Maryland Medical Center, Baltimore, USA.
Insights
Heart failure with preserved ejection fraction (HFpEF) affects many patients but has limited treatment options. This review explores device therapies like implantable cardioverter defibrillators and cardiac resynchronization therapy for HFpEF management.
Area of Science:
- Cardiology
- Medical Devices
Background:
- Heart failure with preserved ejection fraction (HFpEF) accounts for half of all heart failure cases.
- HFpEF patients exhibit preserved systolic function but impaired diastolic function, causing heart failure symptoms.
- Despite increased understanding, HFpEF therapies remain limited compared to heart failure with reduced ejection fraction (HFrEF).
Purpose of the Study:
- To review the current applications of device therapy in patients diagnosed with HFpEF.
- To specifically examine the roles of implantable cardioverter defibrillators (ICDs) and cardiac resynchronization therapy (CRT) in HFpEF management.
Main Methods:
- This is a review article, synthesizing existing literature on device therapy for HFpEF.
- Focus is placed on studies and clinical data concerning ICDs and CRT in the HFpEF population.
Main Results:
- The abstract indicates a focus on device therapy but does not present specific results.
- The review aims to highlight the potential benefits and current limitations of ICDs and CRT in HFpEF.
Conclusions:
- Device therapies, including ICDs and CRT, represent an area of investigation for managing HFpEF.
- Further research and clinical trials are likely needed to establish definitive roles for these devices in HFpEF treatment.
Abstract:
Heart failure with preserved ejection fraction (HFpEF) comprises half of the total heart failure (HF) population. It is a unique class of patients whose systolic heart function is preserved but have impaired diastolic function leading to symptoms typical of HF. In the era of 1980s and 1990s, 'congestive heart failure' was used to refer to all the HF patients. With a better understanding of pathophysiology of 'diastolic HF', the term 'HFpEF' got widespread acceptance in early 2000s. Despite the increasing awareness of pathophysiology and diagnostic modalities for this group of HF patients, it is unfortunate to say that the therapies that we can provide are limited when compared to their counterpart HF with reduced ejection fraction (HFrEF) group. This review will focus on the use of device therapy in patients with HFpEF, particularly implantable cardioverter defibrillator and cardiac resynchronization therapy.
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