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COVID-19 Clinical Trials: A Primer for the Cardiovascular and Cardio-Oncology Communities

Bonnie Ky1,2, Douglas L Mann3

  • 1Department of Medicine, Division of Cardiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

JACC. Cardiooncology
|April 22, 2020
PubMed

Insights

This review provides essential information on COVID-19 treatments for cardiovascular and cardio-oncology physicians. It covers emerging cardiovascular epidemiology and the rationale behind ongoing clinical trials for severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2).

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Oncology

Background:

  • The COVID-19 pandemic spurred numerous clinical trials for SARS-CoV-2.
  • Many treatments under investigation are repurposed drugs with historical applications.

Purpose of the Study:

  • To equip cardiovascular and cardio-oncology physicians with foundational knowledge on COVID-19.
  • To explain the cardiovascular epidemiology and biological rationale of ongoing COVID-19 therapeutic trials.

Main Methods:

  • Review of existing literature on COVID-19 treatments.
  • Analysis of cardiovascular implications and trial rationales.

Main Results:

  • Identification of repurposed therapeutic agents for COVID-19.
  • Summary of emerging cardiovascular epidemiology related to COVID-19.

Conclusions:

  • Understanding repurposed treatments is crucial for cardiovascular and cardio-oncology specialists.
  • This knowledge supports informed patient care and clinical trial interpretation for COVID-19.
Keywords:
ACE, angiotensin-converting enzymeACE2AT1R, angiotensin II type 1 receptorCI, confidence intervalCOVID-19COVID-19, coronavirus disease-2019CoV, coronavirusFDA, Food and Drug AdministrationIFN, interferonIL, interleukinIQR, interquartile rangeMERS, Middle East respiratory syndromeRAS, renin-angiotensin systemRNA, ribonucleic acidSARS-CoV-2SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2TMPRSS2, transmembrane protease serine 2clinical trialsrenin angiotensin systemsACE2, soluble angiotensin-converting enzyme 2

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