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Periaortic adipose tissue volume is associated with sclerotic changes in the adjacent aortic valve

Mehmet Mustu1, Kadri Murat Gurses2, Mehmet Sertac Alpaydin1

  • 1Department of Cardiology, Konya Training and Research Hospital, University of Health Sciences, Meram, 42090, Konya, Turkey.

The International Journal of Cardiovascular Imaging
|April 22, 2020
PubMed

Insights

Increased periaortic adipose tissue volume is linked to aortic sclerosis. This study found a significant independent association between the volume of fat around the aorta and aortic valve sclerosis, highlighting a potential new risk factor.

Area of Science:

  • Cardiovascular Medicine
  • Radiology
  • Biomedical Engineering

Background:

  • Aortic sclerosis is a known risk factor for cardiovascular events.
  • Visceral adiposity is implicated in atherosclerosis development.
  • The similar pathophysiology suggests a link between periaortic fat and aortic valve sclerosis.

Purpose of the Study:

  • To investigate the association between periaortic adipose tissue volume and aortic valve sclerosis.
  • To determine if periaortic adipose tissue is an independent predictor of aortic sclerosis.

Main Methods:

  • Retrospective study of 80 patients with concurrent MSCT and echocardiography.
  • Echocardiography used to assess aortic sclerosis.
  • Multi-detector computed tomography (MSCT) used to calculate periaortic adipose tissue volume.
  • Multivariate regression analysis performed to identify independent associations.

Main Results:

  • Patients with aortic sclerosis had significantly higher periaortic adipose tissue volume compared to controls.
  • Higher levels of BUN, uric acid, and LDL-C were observed in the patient group.
  • Periaortic adipose tissue volume was independently associated with the presence of aortic sclerosis (OR 0.241, p=0.001).

Conclusions:

  • Periaortic adipose tissue volume is independently associated with aortic sclerosis.
  • This finding suggests a novel link between localized visceral fat and aortic valve pathology.
  • Further research may explore therapeutic strategies targeting periaortic fat to mitigate aortic sclerosis risk.

Keywords:
Aortic sclerosisMulti-slice computed tomographyPeriaortic adipose tissue

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