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Functional differentiation in the human ventromedial frontal lobe: A data-driven parcellation
Henry W Chase1, Anthony A Grace1,2, Peter T Fox3,4,5,6
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Human Brain Mapping
|April 22, 2020
Summary
Researchers identified six distinct subregions within the ventromedial frontal lobe (vmFL) using functional connectivity. These findings reveal distinct neural structures crucial for decision-making and emotional regulation.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Neuroanatomy
Background:
- The ventromedial frontal lobe (vmFL) is critical for decision-making and emotional regulation.
- Its detailed functional organization, subregional divisions, and cross-species homologies are not fully understood.
Purpose of the Study:
- To delineate distinct functional subregions within the human vmFL.
- To characterize their functional and anatomical connectivity.
- To explore cross-species homologies.
Main Methods:
- A two-stage parcellation approach based on functional connectivity data.
- Meta-Analytic Connectivity Modeling (MACM) to identify subregions.
- Resting-state fMRI and functional decoding (Brain Map database) for characterization.
Main Results:
- Six distinct subregions were identified within the vmFL, organized rostrocaudally.
- Subregions showed differential functional connectivity with default mode network and striatal regions.
- Findings align with existing anatomical data and animal models.
Conclusions:
- The vmFL comprises functionally distinct subregions.
- These subregions exhibit unique connectivity profiles.
- The study provides a framework for understanding vmFL organization across species.
Keywords:
connectivity-based parcellationfunctional decodingmeta-analytic connectivity modelingresting-state fMRIventromedial frontal lobeMore Related Videos
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