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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Guselkumab in the treatment of moderate-to-severe plaque psoriasis

Cristina López-Sánchez1, Lluís Puig1

  • 1Department of Dermatology, Hospital de la Santa Creu i Sant Pau. Autonomous University of Barcelona, Mas Casanovas 90. 08041 Barcelona, Catalonia, Spain.

Immunotherapy
|April 22, 2020
PubMed

Recent advances in our understanding of the immunopathogenesis of psoriasis have resulted in novel therapeutic agents. IL-23, mainly produced by dendritic cells, maintains the differentiation of naive T cells to Th17 cells, the keystone effector cells in psoriasis. The clinical effectiveness of therapeutic agents targeting this cytokine has been demonstrated in moderate-to-severe plaque psoriasis. Guselkumab is the first human antibody against the p40 subunit of the IL-23 receptor approved by the US FDA and the EMA for this indication in adult patients (2017). It has also been approved for treatment of psoriatic arthritis in Japan (April 2018). This article reviews the published data relating to the efficacy and safety of guselkumab for treatment of moderate-to-severe plaque psoriasis.

Keywords:
IL-23biologicguselkumabp19psoriasisreviewtreatment

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