Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.4K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Septic Cardiomyopathy in the ICU: Echocardiographic Phenotypes, Global Longitudinal Strain, and Right Ventricular Assessment.

Diagnostics (Basel, Switzerland)·2026
Same author

Military Patient Blood Management as a Critical Factor in Combat-Related Septic Reconstructive Surgery: A Case Report.

Military medicine·2026
Same author

Short-term maternal outcomes after intraoperative administration of prophylactic oxytocin during cesarean sections: a retrospective cohort study with a comparison of different administration protocols.

Archives of gynecology and obstetrics·2026
Same author

Clinical Characteristics and Outcomes of 1894 Women with Peripartum Cardiomyopathy Treated with and Without Levosimendan in Germany.

Journal of cardiovascular development and disease·2026
Same author

Who Needs Most? Multicenter Subanalysis of Blood Transfusion Profiles in the German Patient Blood Management Network Registry.

Journal of clinical medicine·2026
Same author

Using a Wearable-Based Animated Patient Avatar to Improve Patients' Perception of Vital Signs: Multicenter Computer-Based Study.

JMIR formative research·2026

Related Experiment Video

Updated: Dec 23, 2025

Application of Hemostatic Devices in Laparoscopic Hepatectomy
04:23

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

2.6K

Hemostatis Analyzer-Supported Hemotherapy Algorithm in Cardiac Surgery: Protocol for a Randomized Controlled

Sophie Michel1, Florian Piekarski1, Jan-Hendrik Fischer1

  • 1Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

JMIR Research Protocols
|April 22, 2020
PubMed
Summary
This summary is machine-generated.

This study validates a new Quantra system algorithm for managing bleeding in cardiac surgery patients, showing it is not inferior to existing methods for reducing blood loss.

Keywords:
MultiplateQuantraalgorithmbypasscardiothoracic surgerycoagulopathypoint of carerotational thromboelastometry

More Related Videos

A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine
08:27

A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine

Published on: December 6, 2024

579
Simple and Effective Procedure for Hemostasis in Mouse Arteries
05:33

Simple and Effective Procedure for Hemostasis in Mouse Arteries

Published on: November 28, 2025

82

Related Experiment Videos

Last Updated: Dec 23, 2025

Application of Hemostatic Devices in Laparoscopic Hepatectomy
04:23

Application of Hemostatic Devices in Laparoscopic Hepatectomy

Published on: April 19, 2022

2.6K
A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine
08:27

A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine

Published on: December 6, 2024

579
Simple and Effective Procedure for Hemostasis in Mouse Arteries
05:33

Simple and Effective Procedure for Hemostasis in Mouse Arteries

Published on: November 28, 2025

82

Area of Science:

  • Coagulation medicine
  • Point-of-care diagnostics
  • Medical device technology

Background:

  • Point-of-care devices for targeted coagulation substitution are crucial for bleeding patients.
  • The Quantra device, utilizing novel ultrasound-based sonorheometry, measures whole blood viscoelastic properties.
  • Existing studies demonstrate Quantra's comparability with established devices like rotational thromboelastometry (ROTEM).

Purpose of the Study:

  • To prospectively investigate the noninferiority of a new Quantra-based algorithm versus a ROTEM/Multiplate system algorithm.
  • To evaluate the efficacy of the Quantra system in managing coagulopathy in cardiac surgical patients.
  • To establish a novel hemotherapy algorithm for cardiac surgery using Quantra technology.

Main Methods:

  • A two-phase study involving observation and intervention.
  • Analysis of whole blood samples from 20 cardiac surgery patients at three critical time points.
  • Development and noninferiority testing of a new hemotherapy algorithm against a standard algorithm.

Main Results:

  • The primary endpoint is cumulative blood loss within 24 hours post-surgery.
  • Statistical analysis indicates the new algorithm is noninferior if blood loss difference is <150 mL/24 hours.
  • The study aims to demonstrate comparable or improved outcomes in blood loss management.

Conclusions:

  • The Quantra sonorheometry system is comparable to ROTEM measurement methods.
  • The established hemotherapy algorithm can be adapted for the Quantra device.
  • Proof of noninferiority supports the clinical adoption of the Quantra system in cardiac surgery.