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DNA Editing for Amyotrophic Lateral Sclerosis: Leading Off First Base

Thomas J Cunningham1, Elizabeth Fisher2, Pietro Fratta2

  • 1Mammalian Genetics Unit, MRC Harwell Institute, Didcot, United Kingdom.

The CRISPR Journal
|April 22, 2020
PubMed
Summary

No abstract available in PubMed .

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RNA editing is a post-transcriptional modification where a precursor mRNA (pre-mRNA) nucleotide sequence is changed by base insertion, deletion, or modification. The extent of RNA editing varies from a few hundred bases, in mitochondrial DNA of trypanosomes, to a just single base, in nuclear genes of mammals. Even a single base change in the pre-mRNA can convert a codon for one amino acid into the codon for another amino acid or a stop codon. This type of re-coding can significantly affect the...
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