Lymphomatosis cerebri with cauda equina lymphoma
Gang Deng1, Ran Tao1, Dai-Shi Tian1
1Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The International Journal of Neuroscience
|April 22, 2020
Summary
Lymphomatosis cerebri (LC) with cauda equina involvement is rare. Multimodal imaging and diagnostics are crucial for timely diagnosis of this primary central nervous system lymphoma (PCNSL).
Area of Science:
- Neurology
- Oncology
- Radiology
Background:
- Lymphomatosis cerebri (LC) and cauda equina lymphoma are rare primary central nervous system lymphomas (PCNSL).
- LC presents as diffuse, bilateral, non-enhancing or partially enhancing infiltrative lesions without mass effect, mimicking leukoencephalopathies.
- Diagnostic delays for LC are common due to its subtle presentation.
Observation:
- This report details the first documented case of LC concurrently involving the cauda equina.
- Diagnosis was confirmed via stereotactic brain biopsy.
Findings:
- The case underscores the challenges in diagnosing LC due to its infiltrative nature.
- Concurrent cauda equina involvement presents a unique diagnostic scenario.
Implications:
- A multimodal diagnostic strategy is essential for accurate and timely PCNSL diagnosis.
- Recommended modalities include multimodal magnetic resonance imaging, cerebrospinal fluid cytology, flow cytometry, and FDG-PET/CT.
- Early and accurate diagnosis is critical for effective management of PCNSL.
