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Updated: Dec 23, 2025

Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training
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Elevated Troponin in Patients With Coronavirus Disease 2019: Possible Mechanisms

Gregorio Tersalvi1, Marco Vicenzi2, Davide Calabretta3

  • 1Division of Cardiology, Fondazione Cardiocentro Ticino, Lugano, Switzerland; Department of Internal Medicine, Hirslanden Klinik St. Anna, Lucerne, Switzerland.

Journal of Cardiac Failure
|April 22, 2020
PubMed

Insights

Elevated cardiac troponin indicates myocardial injury in patients with Coronavirus disease 2019 (COVID-19). This heart muscle damage is linked to severe illness and higher mortality rates in COVID-19 patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pathophysiology

Background:

  • Coronavirus disease 2019 (COVID-19) is a global pandemic causing significant mortality.
  • Critical COVID-19 presentations often involve overwhelmed healthcare systems.
  • Elevated cardiac troponin levels have been observed in a substantial proportion of COVID-19 patients.

Purpose of the Study:

  • To explore the association between COVID-19 and myocardial injury.
  • To review the evidence linking cardiac troponin levels to COVID-19 severity and outcomes.

Main Methods:

  • Literature review of studies analyzing COVID-19 patient data.
  • Examination of evidence on myocardial injury markers, specifically cardiac troponin.
  • Analysis of the correlation between troponin levels and patient mortality.

Main Results:

  • Elevated cardiac troponin is a frequent finding in COVID-19 patients.
  • Myocardial injury is implicated as a pathogenic mechanism in severe COVID-19.
  • High troponin levels are significantly associated with increased mortality in COVID-19.

Conclusions:

  • Myocardial injury, indicated by elevated cardiac troponin, is a critical factor in COVID-19 prognosis.
  • Cardiac troponin levels serve as a potential biomarker for predicting mortality in COVID-19 patients.
  • Understanding the link between COVID-19 and myocardial injury is crucial for patient management.

Keywords:
COVID-19CoronavirusMyocardial injuryMyocarditisSARSTroponin

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