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Members Made of Elastoplastic Material

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Related Experiment Video

Updated: Dec 23, 2025

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs

Microgel-Extracellular Matrix Composite Support for the Embedded 3D Printing of Human Neural Constructs

Published on: May 5, 2023

Freeform 3D printing using a continuous viscoelastic supporting matrix.

Sónia G Patrício^1,2,3, Liliana R Sousa^1,4,2, Tiago R Correia¹

¹Department of Chemistry, CICECO-Aveiro Institute of Materials, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.

|April 22, 2020

Summary

This summary is machine-generated.

Xanthan gum (XG) is a novel, cost-effective support material for embedded 3D bioprinting. Its unique properties enable the creation of complex, large-scale tissue constructs for personalized medicine and advanced in vitro models.

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Area of Science:

Biomaterials Science
Tissue Engineering
3D Bioprinting

Background:

Embedded 3D bioprinting advances soft tissue construct fabrication by providing support for shape maintenance.
Current supporting materials limit the up-scaling of bioprinting for clinically relevant dimensions.

Purpose of the Study:

To introduce xanthan gum (XG) as a cost-effective and widely available supporting material for embedded 3D bioprinting.
To demonstrate the capability of XG to enable the fabrication of complex, large-scale tissue-like constructs.

Main Methods:

Utilized xanthan gum (XG), a natural polysaccharide, as a continuous pseudo-plastic matrix for embedded bioprinting.
Leveraged XG's rheological properties for rapid generation of complex 3D constructs with out-of-plane features.
Engineered perfused cell-laden hydrogel constructs using XG as a photocurable gel reservoir.

Main Results:

Successfully generated complex volumetric 3D constructs with freeform shapes and out-of-plane features.
Demonstrated the potential for on-demand production of large, arbitrary shapes for personalized medicine applications.
Showcased XG's versatility in creating perfused cell-laden hydrogel constructs for in vitro models and organ-on-chip platforms.

Conclusions:

Xanthan gum (XG) is a promising, cost-effective support material for advancing embedded 3D bioprinting technology.
XG facilitates the creation of intricate, large-scale tissue constructs, opening avenues for personalized medicine.
The material's functionality extends to developing advanced biomedical applications like organ-on-chip systems.