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Prevention and Treatment of Venous Thromboembolism Associated with Coronavirus Disease 2019 Infection: A Consensus

Zhenguo Zhai1,2,3, Chenghong Li4, Yaolong Chen5

  • 1Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Thrombosis and Haemostasis
|April 22, 2020
PubMed

Insights

This expert consensus provides guidance on managing venous thromboembolism (VTE) in COVID-19 patients. It offers practical recommendations for prophylaxis and treatment, addressing challenges in antithrombotic therapy for coronavirus disease 2019.

Area of Science:

  • Internal Medicine
  • Infectious Diseases
  • Hematology

Background:

  • Coronavirus disease 2019 (COVID-19) has led to a global pandemic.
  • Severe coagulation abnormalities are observed in nearly 20% of COVID-19 patients, particularly in severe and critical cases.
  • Venous thromboembolism (VTE) is frequently reported in COVID-19, complicating patient management.

Purpose of the Study:

  • To develop an evidence and opinion-based consensus on VTE prophylaxis and management in COVID-19.
  • To provide practical recommendations for clinicians treating COVID-19 patients with VTE.
  • To address the complexities of antithrombotic therapy in the context of COVID-19-associated coagulation disorders.

Main Methods:

  • A comprehensive literature review was conducted.
  • Frontline practical experience from experts and physicians in China and Europe was incorporated.
  • An expert consensus statement was developed based on gathered evidence and opinions.

Main Results:

  • The consensus offers detailed recommendations for VTE prophylaxis and management in COVID-19.
  • Guidance is provided on selecting thromboprophylactic measures based on disease severity and bleeding risk.
  • Recommendations cover the choice of anticoagulant therapies for COVID-19-associated VTE.

Conclusions:

  • This expert consensus statement provides crucial guidance for clinicians managing VTE in COVID-19 patients.
  • The recommendations aim to assist healthcare professionals worldwide in addressing the challenges of COVID-19-associated VTE.
  • The consensus offers specific suggestions to improve patient care and outcomes related to VTE in the context of the pandemic.

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