Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transmission-based Precautions I: Contact, Enteric, and Droplets01:17

Transmission-based Precautions I: Contact, Enteric, and Droplets

4.4K
Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
Contact precautions are the measures taken to prevent the transmission of infectious agents, especially epidemiologically important microorganisms such as MRSA or influenza, primarily transmitted through direct or indirect contact with an...
4.4K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

149
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
149
Standard Precaution01:26

Standard Precaution

2.6K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
2.6K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

177
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
177
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

1.8K
Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.8K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

3.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Restoring Microbial Balance: Clinical Applications, Challenges, and Future Directions of Fecal Microbiota Transplantation in Pediatric Disorders.

Microorganisms·2026
Same author

Evidence-Based Clinical Recommendations for the Appropriate Use of Diagnostic Tests in Pediatric Allergology: Focus on Asthma, Rhinoconjunctivitis, and Keratoconjunctivitis Vernal.

Journal of clinical medicine·2026
Same author

Endocrine and Digestive Disorders Arising in Childhood in Down Syndrome and Their Cross-Talk.

Nutrients·2026
Same author

Fixed Dose Combinations as an Advantage for the Treatment of Pediatric Tuberculosis: A Narrative Review.

Pharmaceuticals (Basel, Switzerland)·2026
Same author

Vaccination Against Serogroup B Meningococcal Disease: Current Status and Future Perspectives-A Consensus Document of the World Association for Infectious Diseases and Immunological Disorders (WAidid).

Vaccines·2026
Same author

Genetic and Clinical Characterization of TANGO2 Deficiency Disorder: Insights from the Italian Multicentre Cohort.

International journal of molecular sciences·2026

Related Experiment Video

Updated: Dec 23, 2025

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
11:13

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

39.7K

Updated Management Guidelines for Clostridioides difficile in Paediatrics.

Margherita Gnocchi1, Martina Gagliardi1, Pierpacifico Gismondi1

  • 1Pediatric Clinic, Pietro Barilla Children's Hospital, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy.

Pathogens (Basel, Switzerland)
|April 23, 2020
PubMed
Summary
This summary is machine-generated.

Diagnosing Clostridioides difficile infections (CDI) in children requires careful consideration of various lab methods, as no single test is perfect. Treatment strategies are evolving, with new options like fidaxomicin and fecal microbiota transplantation offering improved outcomes.

Keywords:
Clostridioides difficileClostridium difficile infectionfaecal microbiota transplantfidaxomicinvancomycin

More Related Videos

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.0K
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.3K

Related Experiment Videos

Last Updated: Dec 23, 2025

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment
11:13

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

39.7K
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

13.0K
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

9.3K

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Microbiology
  • Gastroenterology

Background:

  • Clostridioides difficile infections (CDI) range from mild diarrhea to life-threatening conditions.
  • Prompt diagnosis and treatment are crucial for managing CDI and preventing transmission.

Purpose of the Study:

  • To review current diagnostic laboratory methods for C. difficile detection in children.
  • To discuss updated recommendations for pediatric CDI treatment.

Main Methods:

  • Review of available diagnostic laboratory techniques for C. difficile.
  • Analysis of current treatment guidelines and emerging therapies for pediatric CDI.

Main Results:

  • No single diagnostic test for C. difficile offers optimal sensitivity, specificity, cost, and speed.
  • Treatment approaches vary based on patient age, infection severity, and recurrence.
  • New antibiotics (fidaxomicin), fecal microbiota transplantation, monoclonal antibodies, and vaccines are emerging options.

Conclusions:

  • Optimal C. difficile diagnostics are still under development.
  • Current pediatric CDI treatment prioritizes antibiotic de-escalation and vancomycin or metronidazole.
  • Fidaxomicin, fecal microbiota transplantation, and future therapies hold promise for managing recurrent and severe CDI in children.