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The Associations between Liver Enzymes and Cardiovascular Risk Factors in Adults with Mild Dyslipidemia

Eun-Ock Park1, Eun Ju Bae2, Byung-Hyun Park3

  • 1Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju 54907, Jeonbuk, Korea.

Journal of Clinical Medicine
|April 23, 2020
PubMed

Insights

Elevated liver enzymes like gamma-glutamyltransferase (GGT) are linked to increased cardiovascular disease (CVD) risk in individuals with mild dyslipidemia. Routine GGT screening can aid early CVD detection in these patients.

Area of Science:

  • Cardiology
  • Hepatology
  • Clinical Biochemistry

Background:

  • Hypertension and dyslipidemia are significant cardiovascular disease (CVD) risk factors.
  • Abnormal liver function tests may indicate heightened CVD risk, even with mild dyslipidemia.

Purpose of the Study:

  • To investigate the relationship between liver enzymes and cardiovascular risk factors in patients with mild dyslipidemia.
  • To determine if liver enzymes can predict cardiovascular risk in this population.

Main Methods:

  • Analysis of 438 participants from nine clinical studies (2009-2019) at Chonbuk National University Hospital.
  • Assessment of trends in blood pressure and cardiovascular risk factors across quartiles of serum liver enzymes (GGT, ALT, AST, ALP).
  • Multivariate logistic regression analysis to determine odds ratios for hypertension adjusted for lifestyle factors.

Main Results:

  • Significant linear increases in blood pressure and cardiovascular risk factors were observed with rising GGT and ALT levels.
  • Hypertension prevalence increased across GGT and ALT quartiles.
  • Highest GGT quartile showed a 3.688 odds ratio for hypertension, indicating GGT as a strong predictor.

Conclusions:

  • Gamma-glutamyltransferase (GGT) is a superior marker for predicting CVD risk among liver enzymes in patients with mild dyslipidemia.
  • Routine plasma GGT screening can facilitate early CVD detection in individuals with mild dyslipidemia.

Keywords:
cardiovascular risk factordyslipidemiahypertensionliver enzymes

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