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Updated: Dec 23, 2025

Monitoring Protein Adsorption with Solid-state Nanopores
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Application of Solid-State Nanopore in Protein Detection.

Yuhan Luo1, Linlin Wu1, Jing Tu1

  • 1State Key Lab of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.

International Journal of Molecular Sciences
|April 23, 2020
PubMed
Summary

Solid-state nanopore technology offers a sensitive, single-molecule approach for protein analysis, overcoming limitations of existing proteomics methods. This review details advancements in protein detection and sequencing using nanopores.

Keywords:
protein conformationprotein sequencingsingle molecule detectionsolid-state nanopore

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Area of Science:

  • Biochemistry and Molecular Biology
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Proteins are crucial biomacromolecules containing vital information for physiological processes.
  • Current proteomics technologies face limitations, including chemical modification constraints and high sample volume requirements.
  • Existing methods hinder comprehensive protein analysis and understanding of biological functions.

Purpose of the Study:

  • To review and categorize recent advancements in protein analysis using solid-state nanopore technology.
  • To discuss the capabilities and limitations of nanopore-based protein detection and sequencing.
  • To highlight the potential of solid-state nanopores in overcoming current proteomics challenges.

Main Methods:

  • Solid-state nanopore sensing for single-molecule detection.
  • Analysis of protein structure and sequence through nanopore interactions.
  • Categorization of various nanopore-based protein analysis techniques.

Main Results:

  • Solid-state nanopores enable high-sensitivity, single-molecule protein detection.
  • Nanopore technology shows promise for protein structure discrimination and sequencing.
  • The approach circumvents some limitations of traditional proteomics methods.

Conclusions:

  • Solid-state nanopore technology represents a significant advancement in proteomics.
  • Further development holds potential for revolutionizing protein analysis and biological research.
  • Nanopore-based methods offer a robust and sensitive alternative for studying proteins.