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Related Concept Videos

RNA Splicing01:32

RNA Splicing

60.1K
Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing02:18

Alternative RNA Splicing

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
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Updated: Dec 23, 2025

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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Improving AML Classification Using Splicing Signatures.

Teresa V Bowman1

  • 1Departments of Developmental & Molecular Biology and Medicine (Oncology), Gottesman Institute for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York. teresa.bowman@einsteinmed.org.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|April 23, 2020
PubMed
Summary
This summary is machine-generated.

Aberrant splicing is common in acute myeloid leukemia (AML) and other myeloid cancers. Targeting stress responses linked to splicing dysfunction may offer new therapeutic strategies for these diseases.

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Area of Science:

  • Molecular biology
  • Oncology
  • Hematology

Background:

  • Mutations in spliceosomal components are frequent in myelodysplastic syndromes but less common in acute myeloid leukemia (AML).
  • Despite fewer spliceosomal mutations, aberrant splicing is widespread in AML.
  • Splicing dysfunction is linked to elevated stress responses in myeloid malignancies.

Purpose of the Study:

  • To investigate the role of aberrant splicing in acute myeloid leukemia (AML) tumorigenesis.
  • To explore the connection between stress responses and splicing dysfunction in myeloid malignancies.
  • To identify potential novel therapeutic targets based on splicing dysregulation and stress pathways.

Main Methods:

  • Analysis of splicing patterns in AML and myelodysplastic syndromes.
  • Correlation studies between stress response markers and splicing defects.
  • Evaluation of therapeutic potential of targeting stress-splicing axis.

Main Results:

  • Aberrant splicing is a prolific feature of AML, indicating its contribution to cancer development.
  • Elevated stress responses are associated with splicing dysfunction across various myeloid malignancies.
  • This association highlights a potential vulnerability in cancer cells.

Conclusions:

  • Deregulation of splicing, not just mutations in spliceosomal components, is crucial in AML pathogenesis.
  • The link between stress responses and splicing dysfunction presents a promising avenue for novel cancer therapies.
  • Targeting these pathways could offer new treatment options for patients with myeloid malignancies.