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Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Comparison of structural and functional tests in primary open angle glaucoma.

Umut Karaca1, Ozan Dagli2, Gokhan Ozge3

  • 1Isparta Suleyman Demirel University Faculty of Medicine Department of Ophthalmology Isparta, Turkey.

Indian Journal of Ophthalmology
|April 23, 2020
PubMed
Summary

Glaucoma diagnosis benefits from combining structural and functional tests. Steady-state pattern electroretinography (ssPERG) shows significant correlation with optical coherence tomography (OCT) for better patient management.

Keywords:
Electroretinographyoptical coherence tomographyprimary open angle glaucomavisual field

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Area of Science:

  • Ophthalmology
  • Neuroscience

Background:

  • Glaucoma diagnosis and management rely on various structural and functional tests.
  • Evaluating the relationship between anatomical changes and functional deficits is crucial for understanding glaucoma progression.

Purpose of the Study:

  • To comparatively analyze the diagnostic and follow-up utility of structural and functional tests for glaucoma.
  • To assess the correlation between different glaucoma assessment methods.

Main Methods:

  • Study included 40 primary open-angle glaucoma (POAG) patients and 23 healthy controls.
  • Tests performed: transient pattern electroretinography (PERG), steady-state PERG (ssPERG), visual field (VF) screening, and optical coherence tomography (OCT) for RNFL and macular thickness.

Main Results:

  • POAG patients showed significant delays in PERG and ssPERG latency.
  • Wave amplitudes were significantly lower in POAG patients for both PERG and ssPERG, with ssPERG showing more pronounced differences.
  • ssPERG amplitude correlated positively with VF mean deviation and negatively with VF pattern standard deviation.

Conclusions:

  • Integrated assessment of structural and functional tests is vital for glaucoma management, moving beyond simple cell loss.
  • Steady-state PERG (ssPERG), though not routine, offers valuable insights and correlates significantly with OCT parameters.