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Polymorphisms in CRYBB2 encoding βB2-crystallin are associated with antisaccade performance and memory function.

Ina Giegling1, Annette M Hartmann1, Just Genius2

  • 1Department of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.

Translational Psychiatry
|April 23, 2020
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Summary
This summary is machine-generated.

Beta-B2 crystallin (CRYBB2) impacts brain functions like memory and visual-motor control in humans. While not directly linked to schizophrenia, its expression levels correlate with cognitive performance and sensorimotor gating.

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Area of Science:

  • Neuroscience
  • Genetics
  • Ophthalmology

Background:

  • Beta-B2 crystallin (CRYBB2) is a lens protein found in brain regions like the hippocampus.
  • Mouse Crybb2 mutations affect sensorimotor gating (prepulse inhibition) and interneuron numbers, mirroring schizophrenia endophenotypes.

Purpose of the Study:

  • To investigate the association between CRYBB2 gene variations and schizophrenia endophenotypes in humans.
  • To explore the role of CRYBB2 in cognitive functions and sensorimotor gating.

Main Methods:

  • Genotyped 27 single nucleotide polymorphisms (SNPs) in CRYBB2 and flanking regions in 510 schizophrenia patients and 1322 healthy controls.
  • Assessed schizophrenia-related endophenotypes including antisaccade task performance, working memory, and sensorimotor gating (P50 ratio).
  • Measured CRYBB2 mRNA expression and analyzed functional magnetic resonance imaging (fMRI) signals.

Main Results:

  • No direct association between CRYBB2 SNPs and schizophrenia was found.
  • Decreased CRYBB2 mRNA expression was linked to specific haplotype blocks.
  • These haplotype blocks correlated with poorer antisaccade performance, altered working memory fMRI signals, and reduced sensorimotor gating (P50 ratio).
  • Findings were observed in both patients and controls, indicating a general role in cognitive function.

Conclusions:

  • CRYBB2 plays a significant role in human antisaccade performance and memory function.
  • The study highlights CRYBB2's involvement in brain functions beyond its structural role in the eye.
  • These findings provide new insights into the neurobiological functions of CRYBB2.