Related Experiment Video

Updated: Dec 23, 2025

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

3.0K

The clinical data from 19 critically ill patients with coronavirus disease 2019: a single-centered, retrospective,

Jinping Zhang1, Peng Liu2, Morong Wang1

  • 1ICU, Liyuan Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430071 China.

Zeitschrift Fur Gesundheitswissenschaften = Journal of Public Health
|April 23, 2020
PubMed

Insights

This study analyzed 19 critically ill coronavirus disease 2019 (COVID-19) patients, finding ground-glass changes on CT scans and elevated inflammatory markers. Higher D-dimer levels were observed in non-survivors, indicating its prognostic value.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Radiology

Background:

  • Coronavirus disease 2019 (COVID-19) presents a significant global health challenge.
  • Understanding the clinical spectrum and diagnostic markers of severe COVID-19 is crucial for patient management.

Purpose of the Study:

  • To analyze the clinical features of COVID-19 patients.
  • To evaluate diagnostic and treatment strategies for severe COVID-19 cases.

Main Methods:

  • Retrospective analysis of 19 COVID-19 patients admitted to the ICU.
  • Review of clinical manifestations, auxiliary examinations, and laboratory indices.

Main Results:

  • Median age of patients was 73 years; 42.1% mortality rate.
  • Common symptoms included fever (68.4%) and dry cough (15.8%).
  • All patients showed ground-glass changes on chest CT; elevated hs-CRP and SAA were noted. D-dimer levels were significantly higher in non-survivors.

Conclusions:

  • Critically ill COVID-19 patients often present with specific radiological findings and laboratory abnormalities.
  • Elevated D-dimer levels may serve as a key indicator of poor prognosis in severe COVID-19.
Abstract

Keywords:
Clinical manifestationsCoronavirus disease 2019D-dimerEpidemiologyRetrospective

More Related Videos

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies10:38

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies

Published on: January 16, 2019

20.7K
Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses03:53

Author Spotlight: Advancements in Multiplex Detection of Respiratory Viruses

Published on: November 10, 2023

1.7K

Related Concept Videos

Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
911
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
709
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
661
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
372
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
145
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.0K