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Inspection is the initial step in assessing the cardiovascular system. It involves a detailed visual examination that provides crucial information about a patient's circulatory and cardiac health. This systematic process, conducted from head to toe, helps identify signs of cardiovascular conditions by observing physical appearance, skin and mucous membranes, jugular and carotid pulsations, chest symmetry, and the condition of the extremities.
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Updated: Dec 23, 2025

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Nikolsky's sign: A pathognomic boon.

Subhadeep Maity1, Ishita Banerjee1, Rupam Sinha1

  • 1Department of Oral Medicine and Radiology, Haldia Institute of Dental Sciences and Research, Haldia, West Bengal, India.

Journal of Family Medicine and Primary Care
|April 23, 2020
PubMed
Summary
This summary is machine-generated.

Nikolsky

Keywords:
DislodgementNikolsky's signlateral pressure

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Area of Science:

  • Dermatology and Pathology

Background:

  • Nikolsky's sign is a recognized diagnostic indicator for blistering skin conditions.
  • It is particularly relevant in diagnosing diseases such as pemphigus and toxic epidermal necrolysis.

Purpose of the Study:

  • To elucidate the diagnostic utility of Nikolsky's sign in specific dermatological conditions.
  • To describe the physical maneuver and its implications in blister extension.

Main Methods:

  • The study involves the clinical demonstration of Nikolsky's sign.
  • This includes applying lateral pressure to the edge of intact blisters.

Main Results:

  • Positive Nikolsky's sign results in the dislodgement of the epidermis surrounding an intact blister.
  • This phenomenon leads to the characteristic extension of the blister upon gentle pressure.

Conclusions:

  • Nikolsky's sign is a valuable clinical sign for diagnosing blistering skin disorders.
  • Its demonstration aids in differentiating and confirming conditions like pemphigus and toxic epidermal necrolysis.