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Block copolyurethanes in the urinary system.

S M Bergman, D J Lyman, R G Middleton

    Investigative Urology
    |May 1, 1977
    PubMed
    Summary
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    Block copolyurethane demonstrated superior performance compared to silicone rubber in rat bladders, showing reduced incrustation. Urethane grafts in dog ureters were well-tolerated, with minimal infection and signs of tissue regeneration.

    Area of Science:

    • Biomaterials Science
    • Urology
    • Regenerative Medicine

    Background:

    • Incrustation of implants in the urinary tract remains a significant clinical challenge.
    • Block copolyurethane and silicone rubber are commonly used biomaterials for medical implants.

    Purpose of the Study:

    • To compare the performance of block copolyurethane against silicone rubber in a rat bladder model.
    • To evaluate the biocompatibility and efficacy of urethane grafts in canine ureters.

    Main Methods:

    • Implantation of free-floating segments of block copolyurethane and silicone rubber into rat bladders.
    • Replacement of canine ureter segments with tubular block copolyurethane grafts.
    • Assessment via intravenous urography, monitoring for hydronephrosis and infection.

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    Main Results:

    • Block copolyurethane exhibited significantly less incrustation than silicone rubber in rat bladders.
    • Canine ureter grafts showed minimal incrustation, a proteinaceous coating, and evidence of mucosal and muscle regeneration.
    • While initial hydronephrosis was observed in dogs, it reduced over time; urinary infection was infrequent.

    Conclusions:

    • Block copolyurethane is a superior material to silicone rubber for resisting incrustation in the urinary tract.
    • Urethane grafts demonstrate good biocompatibility and tissue integration potential in the urinary tract of dogs and rats.