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Clinical Trials for the Surgical Oncologist: Opportunities and Hurdles

Ko Un Park1, Eleftherios P Mamounas2, Matthew H G Katz3

  • 1Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Annals of Surgical Oncology
|April 23, 2020
PubMed

Insights

Surgeons play a vital role in advancing surgical oncology through clinical trials. This expert panel explores how surgeons can effectively participate in clinical trials to improve patient care and treatment outcomes.

Area of Science:

  • Oncology
  • Clinical Trials
  • Surgical Oncology

Background:

  • Clinical practice advancements rely on high-level evidence from comparative clinical trials.
  • Slow accrual and adoption of clinical trial results hinder progress in surgical oncology.

Purpose of the Study:

  • To explore the reasons for slow accrual and adoption of clinical trial findings in surgical oncology.
  • To discuss how surgeons can become successfully involved in clinical trials.
  • To highlight the role of surgical oncologists in advancing cancer care through research.

Main Methods:

  • Expert panel discussion on clinical trial infrastructure.
  • Review of investigator-initiated trials and national clinical trial networks.
  • Case studies of two national clinical trials (NSABP B-51/RTOG 1304 and PROSPECT N1048).

Main Results:

  • Discussion of the fundamental infrastructure of clinical trials.
  • Exploration of investigator-initiated trials and the National Clinical Trials Network.
  • Highlighting specific opportunities for surgeon involvement in clinical research.

Conclusions:

  • Successful surgeon involvement is crucial for efficient clinical trial accrual and adoption.
  • Understanding clinical trial infrastructure and networks empowers surgeons to contribute effectively.
  • Participation in trials like NSABP B-51/RTOG 1304 and PROSPECT N1048 demonstrates the impact of surgical oncologists in advancing evidence-based practice.

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