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Purification and Transplantation of Myogenic Progenitor Cell Derived Exosomes to Improve Cardiac Function in Duchenne Muscular Dystrophic Mice
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Do exosomes play role in cardiovascular disease development in hematological malignancy?
Fatemeh Javaherforoosh Zadeh1,2, Yasmin Ghasemi3, Saeede Bagheri4
1Department of Cardiac Anesthesia, Ahvaz Anesthesiology and Pain Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Molecular Biology Reports
|April 23, 2020
Summary
Exosomes impact cancer treatment and cardiovascular disease (CVD) development. Understanding exosome pathways may help prevent CVD by promoting angiogenesis and cardiomyocyte repair.
Area of Science:
- Exosome biology
- Cardiovascular disease pathogenesis
- Cancer therapeutics
Background:
- Exosomes are implicated in malignancy pathogenesis and treatment.
- Emerging roles in cardiomyocyte function impairment and cardiovascular disease (CVD) genesis are noted.
Purpose of the Study:
- To review the dual role of exosomes in cancer and cardiovascular disease.
- To explore exosome-mediated molecular pathways in CVD genesis and potential therapeutic strategies.
Main Methods:
- Literature review of studies up to 2019 from PubMed.
- Analysis of keywords: "Arsenic trioxide", "acute promyelocytic leukemia", "cardiotoxicity", "molecular pathway", "biomarker".
Main Results:
- Exosomes can stimulate angiogenesis and cardiomyocyte repair, dependent on secreted substances.
- Exosomes are generally involved in CVD pathogenesis.
- Identifying pro-angiogenic pathways may offer CVD prevention strategies.
Conclusions:
- Exosomes present a "double-edged sword" in cancer and CVD.
- Targeting exosome-derived pathways offers potential for CVD prevention and treatment.
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