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[Prognostic Analysis of Primary Central Nervous System Lymphoma Patients with Diffuse Large B-Cell Immunophenotype]
Xiao-Hui Fan1, Yan-Qiu Xu1, Feng Zhu2
1Department of Hematology, Xuzhou Medical University Affiliated Hospital , Xuzhou 221000, Jiangsu Province, China.
Objective:
To investigate the prognostic influencing factors of primary central nervous system lymphoma (PCNSL) patients with diffuse large B-cell immunophenotype.
Methods:
42 PCNSL patients with diffuse large B-cell lymphoma treated in our hospital from March 2011 to October 2017 were enrolled. The effects of different treatments on overall survival of patients were analyzied.
Results:
The analysis for 42 PCNSL patients with diffuse large B-cell immunophenotype showed that there was no affect of their clinical characteristics,such as sex, age, CSF protein content, treatment with and without temozolomide and rituximab on overall survival of the patients(P>0.05). And it was found that active treatment and the application of conventional intrathecal injection and methotrexate in the treatment could effectively prolong the overall survival time of patients.
Conclusion:
Early diagnosis of PCNSL and active standardized treatment can significantly prolong the survival time of patients, and it is further emphasized that the necessity of conventional intrathecal injection to prolong the survival of patients.
