[Newest Reaserch Advance on Targeting Glycolysis Pathways in Acute Myeloid Leukemia --Review]

Metabolic reprogramming plays an important role in the occurrence, drug resistance and recurrence of acute myeloid leukemia (AML). Warburg effect is considered to be the most fundamental metabolic alternation in the process of tumor transformation. The enhancement of glycolytic activation was being found in most malignancies including AML, which promotes anabolism and closely relates with the occurrence and development of tumors. Each metabolic process of glycolysis pathway is catalyzed by specific enzymes. The dependence of AML cells on glycolysis makes targeting inhibition of related catalytic enzymes and interference with glycolysis process a promising therapeutic option. In this review, the recent advances in glycolysis pathway-related targeted therapy in AML are summarized.