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[Leukoencephalopathy in the elderly. Binswanger disease?]
G Castorina1, G Aliatis, F Bianco
1Istituto di Clinica delle Malattie Nervose e Mentali, Università La Sapienza, Roma.
Rivista Di Neurologia
|September 1, 1988
Summary
This study explored cerebrovascular disease and periventricular white matter damage using CT scans. Findings suggest age is a significant factor in these lesions, even without vascular disease.
Area of Science:
- Neurology
- Radiology
Background:
- Cerebrovascular disease can cause acute episodes and cerebral damage.
- Periventricular white matter lesions are associated with Binswanger disease.
Purpose of the Study:
- To investigate the etiopathogenesis of periventricular white matter damage in patients with cerebrovascular disease.
- To correlate these lesions with Binswanger disease.
Main Methods:
- Computed Tomography (CT) scans were used to examine 100 patients with acute cerebrovascular disease.
- Lesions in the periventricular white substance were analyzed.
Main Results:
- Only 7 patients exhibited typical bilateral periventricular white matter lesions.
- Most patients with these lesions were over seventy years old.
- Similar lesion prevalence was observed in individuals over 70 without cerebrovascular disease.
- The single patient with mental impairment had severe periventricular white matter lesions.
Conclusions:
- Age appears to be a significant factor in the development of periventricular white matter lesions.
- The presence and severity of these lesions may be linked to cognitive function, as suggested by the case of mental impairment.