Endoscopic endonasal CSF rhinorrhea repair in children: Systematic review with meta-analysis

Chadi A Makary1, Habib G Zalzal1, Jad Ramadan1

  • 1Department of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, WV, USA.

Insights

Endoscopic repair effectively treats cerebrospinal fluid (CSF) rhinorrhea in children, achieving a 94% success rate after the first attempt. This minimally invasive approach offers a highly successful closure for pediatric CSF leaks.

Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Pediatric Surgery

Background:

  • Cerebrospinal fluid (CSF) rhinorrhea is an uncommon condition in children.
  • Endoscopic repair is the primary treatment for nasal CSF leaks in adults.

Purpose of the Study:

  • To evaluate the success rates of endoscopic repair for cerebrospinal fluid (CSF) rhinorrhea in pediatric patients.
  • To analyze the efficacy of endoscopic techniques in achieving CSF leak cessation in children.

Main Methods:

  • A meta-analysis was conducted, reviewing 15 studies published between January 1990 and September 2019.
  • Data extraction included patient demographics, surgical methods, and outcomes.
  • Literature search performed across MEDLINE, EMBASE, and Cochrane Library.

Main Results:

  • Endoscopic repair demonstrated a pooled weighted success rate of 94% for CSF rhinorrhea in children after the initial procedure.
  • Traumatic and congenital causes were the most frequent etiologies.
  • Iatrogenic defects, often from tumor resections, are an increasing cause of CSF leaks.

Conclusions:

  • Endoscopic repair techniques are highly effective for treating cerebrospinal fluid (CSF) rhinorrhea in pediatric populations.
  • The high success rate is consistent across various endoscopic techniques employed.
Abstract

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