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Endoscopic endonasal CSF rhinorrhea repair in children: Systematic review with meta-analysis
Chadi A Makary1, Habib G Zalzal1, Jad Ramadan1
1Department of Otolaryngology-Head and Neck Surgery, West Virginia University School of Medicine, Morgantown, WV, USA.
Insights
Endoscopic repair effectively treats cerebrospinal fluid (CSF) rhinorrhea in children, achieving a 94% success rate after the first attempt. This minimally invasive approach offers a highly successful closure for pediatric CSF leaks.
Area of Science:
- Otolaryngology
- Neurosurgery
- Pediatric Surgery
Background:
- Cerebrospinal fluid (CSF) rhinorrhea is an uncommon condition in children.
- Endoscopic repair is the primary treatment for nasal CSF leaks in adults.
Purpose of the Study:
- To evaluate the success rates of endoscopic repair for cerebrospinal fluid (CSF) rhinorrhea in pediatric patients.
- To analyze the efficacy of endoscopic techniques in achieving CSF leak cessation in children.
Main Methods:
- A meta-analysis was conducted, reviewing 15 studies published between January 1990 and September 2019.
- Data extraction included patient demographics, surgical methods, and outcomes.
- Literature search performed across MEDLINE, EMBASE, and Cochrane Library.
Main Results:
- Endoscopic repair demonstrated a pooled weighted success rate of 94% for CSF rhinorrhea in children after the initial procedure.
- Traumatic and congenital causes were the most frequent etiologies.
- Iatrogenic defects, often from tumor resections, are an increasing cause of CSF leaks.
Conclusions:
- Endoscopic repair techniques are highly effective for treating cerebrospinal fluid (CSF) rhinorrhea in pediatric populations.
- The high success rate is consistent across various endoscopic techniques employed.
Objectives:
Cerebrospinal fluid (CSF) rhinorrhea in children is relatively uncommon. Endoscopic repair techniques in adults have become first line for nasal-based CSF leaks, and this meta-analysis looks at the success rates of CSF leak cessation following endoscopic repair in children.
Methods:
Three researchers extracted information involving patient population, surgical technique, outcomes of interest, and study design. A computerized search of MEDLINE, EMBASE and the Cochrane library (January 1990-September 2019) looked for several papers on the subject of CSF leak repair in children using endoscopic technique.
Results:
A total of 15 studies met inclusion criteria. Endoscopic repair of CSF rhinorrhea in children shows a pooled weighted success rate of 94% after first attempt. The most common etiology was traumatic followed by congenital. Iatrogenic defects secondary to tumor resection are becoming more common. The high success rate was irrespective of the techniques using.
Conclusion:
Endoscopic repair techniques have a highly successful closure rate for children presenting with CSF rhinorrhea.
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