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Cardiovascular diseases: a therapeutic perspective around the clock.
Ana Cláudia Soares1, Diogo A Fonseca2
1Faculty of Pharmacy, University of Coimbra, Portugal.
Drug Discovery Today
|April 23, 2020
Summary
Circadian rhythms regulate cardiovascular function, but modern lifestyles disrupt this internal clock, increasing cardiovascular disease (CVD) risk. Understanding these biological rhythms may improve CVD therapies.
Area of Science:
- Chronobiology
- Cardiovascular Physiology
- Medical Research
Background:
- Biological systems exhibit ubiquitous circadian rhythms influencing physiological, biochemical, and behavioral processes.
- Circadian fluctuations critically regulate cardiovascular functions, including heart rate, blood pressure, cardiac contractility, and metabolism.
- Modern lifestyles often impose external timing cues that conflict with endogenous circadian rhythms, potentially elevating cardiovascular disease (CVD) risk.
Purpose of the Study:
- To review the modulatory role of circadian rhythms on cardiovascular function and disease.
- To explore the application of chronotherapy in managing CVD.
- To identify potential improvements for existing CVD therapies and aid in the development of novel treatments.
Main Methods:
- Literature review focusing on circadian rhythms and cardiovascular health.
- Analysis of mechanisms underlying circadian rhythm disruption and CVD.
- Examination of chronotherapy principles and their application to cardiovascular medicine.
Main Results:
- Circadian rhythms significantly impact cardiovascular system regulation.
- Disruption of circadian physiology by lifestyle factors is linked to increased CVD risk.
- Chronotherapy presents a promising avenue for enhancing CVD treatment strategies.
Conclusions:
- Circadian rhythms are integral to cardiovascular health and disease.
- Further research into the mechanisms of circadian dysregulation is crucial.
- Chronotherapy holds potential for optimizing cardiovascular disease management and developing innovative therapies.
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