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Related Concept Videos

Essential Minerals for Bone Health01:31

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Increasing fluoride content deteriorates rat bone mechanical properties.

Taraneh Rezaee1, Mary L Bouxsein2, Lamya Karim1

  • 1Department of Bioengineering, University of Massachusetts Dartmouth, 285 Old Westport Road, Dartmouth, MA 02747, USA.

Bone
|April 23, 2020
PubMed
Summary
This summary is machine-generated.

High fluoride intake from sodium fluoride (NaF) exposure in vitro negatively impacts bone strength and mechanical properties. Increased NaF levels in bone tissue led to greater indentation and reduced bone rigidity and strength.

Keywords:
BoneMechanical propertiesReference point indentationSkeletal fluorosisSodium fluoride

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Area of Science:

  • Biomaterials Science
  • Skeletal Biology
  • Materials Science

Background:

  • Elevated bone fluoride levels, from high fluoride intake or inhalation, can cause skeletal fluorosis, leading to joint pain, deformities, and fractures.
  • Skeletal fluorosis alters bone's mineral composition, potentially affecting its mechanical properties at both tissue and whole bone levels.

Purpose of the Study:

  • To investigate the effects of in vitro sodium fluoride (NaF) incubation on bone mechanical behavior at tissue and whole bone levels.
  • To determine if NaF alters bone's mechanical properties independent of bone turnover.

Main Methods:

  • Rat ulnae were incubated with varying concentrations of NaF (0.05 M to 1.5 M).
  • Cyclic reference point indentation (cRPI) assessed tissue-level mechanical properties.
  • Three-point bending tests evaluated whole bone mechanical properties.
  • MicroCT was used to determine cortical tissue mineral density and geometry.

Main Results:

  • NaF incubation increased bone fluoride levels.
  • Increased NaF concentrations resulted in greater indentation distances and higher displacement-to-maximum force.
  • NaF exposure led to a significant decrease in estimated elastic modulus, ultimate stress, and bending rigidity.
  • cRPI variables correlated with whole bone mechanical properties, with higher indentation associated with poorer mechanical outcomes.

Conclusions:

  • In vitro NaF incubation has a deleterious effect on bone mechanical behavior.
  • The negative effects on bone mechanics increase with higher NaF concentrations.
  • These findings suggest NaF impairs bone quality, making it more susceptible to damage, independent of bone turnover.