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Related Experiment Video

Updated: Dec 23, 2025

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

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Published on: October 16, 2010

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Changes in breast density over serial mammograms: A case-control study.

Hanna Sartor1, Despina Kontos2, Susann Ullén3

  • 1Diagnostic Radiology, Department of Translational Medicine, Lund University, Skåne University Hospital, Lund, Sweden.

European Journal of Radiology
|April 23, 2020
PubMed
Summary
This summary is machine-generated.

Women with breast cancer showed a significant increase in breast density over time compared to controls. This change was more pronounced in older women (over 55), suggesting breast density changes may indicate cancer risk.

Keywords:
Breast cancerBreast densityMammography

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Area of Science:

  • Radiology and Imaging
  • Oncology
  • Biostatistics

Background:

  • Breast density is a known risk factor for breast cancer.
  • Temporal changes in breast density are emerging as a dynamic marker for breast cancer risk.
  • Understanding these changes can aid in early detection and risk assessment.

Purpose of the Study:

  • To investigate changes in breast density preceding breast cancer diagnosis.
  • To explore the relationship between breast density changes and prognostic pathological tumor characteristics.

Main Methods:

  • A case-control study involving 51 biopsy-proven breast cancer cases and matched controls.
  • Retrospective retrieval of mammogram data and patient/tumor characteristics.
  • Quantitative breast density estimation using LIBRA software.

Main Results:

  • Cases exhibited a statistically significant increase in breast density (1.7%) compared to controls (-0.3%).
  • Older women (≥ 55 years) with breast cancer showed a higher increase in breast density (5.1%) than younger women (0.3%).

Conclusions:

  • A significant difference in breast density change over time was observed between women with and without breast cancer.
  • Increased breast density over time is associated with breast cancer, particularly in women over 55.
  • Temporal breast density changes may serve as a valuable indicator in breast cancer risk assessment.