Adverse drug events and the associated factors in patients with chronic Chagas disease
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Published on: November 5, 2021
Luiza Braz da Cunha Lopes1, Raquel Rodrigues Pereira1, Patricia Mello Andrade1
1Fundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brasil.
Introduction:
Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients.
Methods:
We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs.
Results:
ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs.
Conclusions:
Close follow-up is warranted for CD patients.
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